Ag Nanoparticles/alpha-Ag2WO4 Composite Formed by Electron Beam and Femtosecond Irradiation as Potent Antifungal and Antitumor Agents
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Date
2019-07-23
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Abstract
The ability to manipulate the structure and function of promising systems via external stimuli is
emerging with the development of reconfgurable and programmable multifunctional materials.
Increasing antifungal and antitumor activity requires novel, efective treatments to be diligently
sought. In this work, the synthesis, characterization, and in vitro biological screening of pure
α-Ag2WO4, irradiated with electrons and with non-focused and focused femtosecond laser beams are
reported. We demonstrate, for the frst time, that Ag nanoparticles/α-Ag2WO4 composite displays
potent antifungal and antitumor activity. This composite had an extreme low inhibition concentration
against Candida albicans, cause the modulation of α-Ag2WO4 perform the fungicidal activity more
efcient. For tumor activity, it was found that the composite showed a high selectivity against the
cancer cells (MB49), thus depleting the populations of cancer cells by necrosis and apoptosis, without
the healthy cells (BALB/3T3) being afected.
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Subject(s)
SILVER NANOPARTICLES, ANTIBACTERIAL ACTIVITY, OXIDATIVE STRESS, PHOTOCATALYTIC ACTIVITY, ALPHA-AG2WO4 NANORODS, IN-VITRO, MECHANISMS, NANOMATERIALS, GENERATION, GROWTH