Ag Nanoparticles/alpha-Ag2WO4 Composite Formed by Electron Beam and Femtosecond Irradiation as Potent Antifungal and Antitumor Agents

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dc.contributor.authorAssisi, M.
dc.contributor.authorRobeldo, T.
dc.contributor.authorFoggi, C. C.
dc.contributor.authorKubo, A. M.
dc.contributor.authorMinguez-Vega, G.
dc.contributor.authorCondoncillo, E.
dc.contributor.authorBeltran-Mir, H.
dc.contributor.authorTorres-Mendieta, R.
dc.contributor.authorAndres, J.
dc.contributor.authorOliva, M.
dc.contributor.authorVergani, C. E.
dc.contributor.authorBarbugli, P. A.
dc.contributor.authorCamargo, E. R.
dc.contributor.authorBorra, R. C.
dc.contributor.authorLongo, E.
dc.date.accessioned2019-07-23T08:19:56Z
dc.date.available2019-07-23T08:19:56Z
dc.date.issued2019-07-23
dc.description.abstractThe ability to manipulate the structure and function of promising systems via external stimuli is emerging with the development of reconfgurable and programmable multifunctional materials. Increasing antifungal and antitumor activity requires novel, efective treatments to be diligently sought. In this work, the synthesis, characterization, and in vitro biological screening of pure α-Ag2WO4, irradiated with electrons and with non-focused and focused femtosecond laser beams are reported. We demonstrate, for the frst time, that Ag nanoparticles/α-Ag2WO4 composite displays potent antifungal and antitumor activity. This composite had an extreme low inhibition concentration against Candida albicans, cause the modulation of α-Ag2WO4 perform the fungicidal activity more efcient. For tumor activity, it was found that the composite showed a high selectivity against the cancer cells (MB49), thus depleting the populations of cancer cells by necrosis and apoptosis, without the healthy cells (BALB/3T3) being afected.cs
dc.format.extent15 strancs
dc.identifier.doi10.1038/s41598-019-46159-y
dc.identifier.urihttps://dspace.tul.cz/handle/15240/152936
dc.language.isocscs
dc.relation.ispartofSCIENTIFIC REPORTS
dc.subjectSILVER NANOPARTICLES
dc.subjectANTIBACTERIAL ACTIVITY
dc.subjectOXIDATIVE STRESS
dc.subjectPHOTOCATALYTIC ACTIVITY
dc.subjectALPHA-AG2WO4 NANORODS
dc.subjectIN-VITRO
dc.subjectMECHANISMS
dc.subjectNANOMATERIALS
dc.subjectGENERATION
dc.subjectGROWTH
dc.titleAg Nanoparticles/alpha-Ag2WO4 Composite Formed by Electron Beam and Femtosecond Irradiation as Potent Antifungal and Antitumor Agentscs
local.relation.volume9
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