Nanočástice hydroxyapatitu a jejich příprava
Loading...
Date
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Tato práce se zabývá nanočásticemi hydroxyapatitu (HAP), konkrétně jejichpřípravou a následnou charakterizací. Teoretická část práce popisuje, jakými metodami je možné hydroxyapatit a jeho nanočástice připravit. Cílem experimentální práce bylo jednu z metod popsaných v teoretické části zvolit a prozkoumat možnosti přípravy nanočástic HAP touto metodou. V této práci byla zvolena metoda precipitační. U ní byl prověřen hlavně vliv procesních parametrů na finální vlastnosti částic, resp. nanočástic, a jak je možné docílit předem určeného složení, struktury a velikosti produktu. Mezi podmínky, které nejvíce ovlivňují tvorbu hydroxyapatitu, patří teplota, pH, koncentrace výchozích látek, správný molární poměr vápníku k fosforu v reaktantech a také dobastárnutí suspenze. Vzniklé nanočástice byly analyzovány pomocí rastrovacíhoelektronového mikroskopu s jednotkou EDS, Ramanova spektrometru a dynamickéhorozptylu světla. U vybraného vzorku byla ověřena také biokompatibilita.
This work is focused on hydroxyapatite (HAP) nanoparticles, especially on theirsynthesis and characterization. Theoretical part of this thesis is focused on review of preparation methods for HAP and HAP nanoparticles synthesis. The aim of this work was to choose and analyze one of these methods. In this work, the precipitation method was chosen. The mostly investigated factors were those affecting the final particle size and properties, and how the predetermined composition, structure and particle size can be achieved The conditions mostly affecting the hydroxyapatite synthesis include temperature, pH, concentration of precursors, correct molar ratio between calcium and phosphorus and also time of solution aging. Formed particles were analysed using scanning electron microscope with electron-dispersive X-ray spectroscopy, Raman spectrometer and Dynamic Light Scattering analysis. One chosen sample was tested on biocompatibility level.
This work is focused on hydroxyapatite (HAP) nanoparticles, especially on theirsynthesis and characterization. Theoretical part of this thesis is focused on review of preparation methods for HAP and HAP nanoparticles synthesis. The aim of this work was to choose and analyze one of these methods. In this work, the precipitation method was chosen. The mostly investigated factors were those affecting the final particle size and properties, and how the predetermined composition, structure and particle size can be achieved The conditions mostly affecting the hydroxyapatite synthesis include temperature, pH, concentration of precursors, correct molar ratio between calcium and phosphorus and also time of solution aging. Formed particles were analysed using scanning electron microscope with electron-dispersive X-ray spectroscopy, Raman spectrometer and Dynamic Light Scattering analysis. One chosen sample was tested on biocompatibility level.
Description
Subject(s)
Hydroxyapatit, nanočástice, metody přípravy hydroxyapatitu, precipitační metoda, Hydroxyapatite, nanoparticles, preparation methodologies, precipitation method