Cyclodextrin-Polypyrrole Coatings of Scaffolds for Tissue Engineering
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Date
2019-03-11
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Abstract
Polypyrrole is one of the most investigated conductive polymers used for tissue engineering
applications because of its advantageous properties and the ability to promote different cell types’
adhesion and proliferation. Together with β-cyclodextrin, which is capable of accommodating
helpful biomolecules in its cavity, it would make a perfect couple for use as a scaffold for tissue
engineering. Such scaffolds were prepared by the polymerisation of 6-(pyrrol-3-yl)hexanoic acid on
polycaprolactone microfibres with subsequent attachment of β-cyclodextrin on the polypyrrole layer.
The materials were deeply characterised by several physical and spectroscopic techniques. Testing of
the cyclodextrin enriched composite scaffold revealed its better performance in in vitro experiments
compared with pristine polycaprolactone or polypyrrole covered polycaprolactone scaffolds.
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Subject(s)
cyclodextrin, pyrrole, polypyrrole, polycaprolactone, functionalisation, microfibres, tissue engineering, scaffold