Studium difuze alaptidu z nanovlákenných vrstev
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V dnešní době je nedostatek studií zabývajících kinetikou uvolňování léčiv z elektrostatický zvlákněných struktur. Ve skutečnosti, ještě méně studií se snaží porovnávat experimentální data s matematickými modely. Tato práce se zabývala studiem vlivu počátečního množství inkorporovaného léčiva a sterilizačních metod na kinetiku uvolňování alaptidu z elektrostaticky zvlákněných vláken polykaprolaktonu (PCL). Se zvyšující se dávkou alaptidu rostla hydrofilnost vrstev a snižovaly se průměry vláken. Ke kvantifikaci uvolňování byla použita metoda GPC. Veškeré průběhy byly dvoufázové, se značným počátečním nárazovým uvolněním a dále pokračovala zpomaleným uvolněním. Kinetika uvolnění byla značně závislá na dávce alaptidu. Sterilizace EtO nezpůsobila žádné patrné změny kinetiky uvolňování. Fitování dosažených dat bylo komplikováno dvoufázovou povahou uvolňování. Práce názorně ukázala úspěšnou výrobu
There is a lack of studies related to drug release kinetics from electrospun fibrous structures nowadays. Indeed, even less studies try to verify to compare experimental data with mathematic models. This study investigated the effects of drug loading and sterilization technics on release kinetics of alaptide from polycaprolactone (PCL) electrospun nanofibrous layers. With the increasing drug loading increased hydrophilicity of the layers and decreased the fiber diameters. The release of alaptide was quantified using GPC. All the release profiles were found to be biphasic, consisting of significant initial burst release and further slow sustained release. The release kinetics were significantly dependent on the initial drug loading, sterilization with EtO did not remarkably affect the release. Fitting of data into mathematical models was complicated due to biphasic character of the release profiles. The study demonstrated successful fabrication of drug-loaded nanofibrous layers, which were able to provide sustained release of alaptide at least for 14 days.
There is a lack of studies related to drug release kinetics from electrospun fibrous structures nowadays. Indeed, even less studies try to verify to compare experimental data with mathematic models. This study investigated the effects of drug loading and sterilization technics on release kinetics of alaptide from polycaprolactone (PCL) electrospun nanofibrous layers. With the increasing drug loading increased hydrophilicity of the layers and decreased the fiber diameters. The release of alaptide was quantified using GPC. All the release profiles were found to be biphasic, consisting of significant initial burst release and further slow sustained release. The release kinetics were significantly dependent on the initial drug loading, sterilization with EtO did not remarkably affect the release. Fitting of data into mathematical models was complicated due to biphasic character of the release profiles. The study demonstrated successful fabrication of drug-loaded nanofibrous layers, which were able to provide sustained release of alaptide at least for 14 days.
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kinetika uvolňování léčiv, alaptid, difuzní rovnice, polykaprolakton, drug release kinetics, alaptide, diffusion equation, polycaprolactone