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- ItemELECTROSPINNING AND MODIFICATION OF FIBROUS MATERIALS WITH BIOMEDICAL POTENTIAL(2025) Lubasová, DanielaThis habilitation thesis comprises a collection of published scientific and research works, accompanied by commentary in accordance with §72 paragraph 3 of Act on universities No. 111/1998 Coll. The thesis comprises commentary on 15 peer-reviewed journal articles, 5 conference papers, 2 national patents, 1 international patent, and 1 book chapter, with the 9 most significant publications included in the appendices. The scientific works focus on the development, electrospinning, modification, and biomedical potential of various fibrous materials. The first chapter discusses electrospinning of copolymers and polymer blends into fibrous materials, aiming to optimize their water resistance, biodegradability, mechanical properties, and absorption capacity. The scalability of needle-less electrospinning is particularly highlighted as it allows bridging laboratory research with industrial production. The second chapter explores advanced modification strategies of electrospun fibrous materials to meet specific biomedical requirements, including improving antibacterial properties, enhancing cellmaterial interactions, and optimizing drug release dynamics. Additionally, a novel predictive numerical model is introduced to optimize fiber morphology based on solvent system properties. The final chapter highlights the biomedical potential of electrospun materials, demonstrating their applicability in bacterial filtration, customised wound care, sublingual drug delivery using mucoadhesive patches, and targeted cancer therapy. This habilitation thesis introduces innovative approaches to scalable production and functional modification of electrospun fibrous materials, underscoring their significance as promising solutions to critical challenges in modern biomedicine.
- ItemDevelopment of Functionalized Fibrous Structures(2025) Venkataraman, MohanapriyaThis habilitation thesis is a set of selected published scientific papers or engineering papers supplemented with a commentary according to §72 paragraph 3-point Act No. 111/1998 Coll. on universities. In total, the full set of scientific paper contains 24 research works published in impact factor journals and 2 published books. The chosen scientific papers are mainly focused on the study of fibrous structures for functional properties. The fibrous structures' peculiarities are explained where the important structural properties, such as porosity, are described. The possibilities of using different materials to boost selected functional properties are discussed. The development of nanoporous membranes by using electrospinning and electrospraying techniques are described. The efficacy of middle layers in multi-layered fibrous structures are detailed and embedding polyethylene glycol in silica aerogel, polytetrafluoroethylene fibrous layer filled with Aerogels and Phase Change Materials, aerogel-coated Kevlar Woven Fabrics, and PEG/Metal particle-coated viscose fabric is also described. The application of advanced structures for enhanced functionality is also provided. The conclusion summarizes this research topic's findings, benefits, and future direction.