ELECTROSPINNING AND MODIFICATION OF FIBROUS MATERIALS WITH BIOMEDICAL POTENTIAL
Loading...
Date
2025
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
This habilitation thesis comprises a collection of published scientific and research works,
accompanied by commentary in accordance with §72 paragraph 3 of Act on universities No.
111/1998 Coll. The thesis comprises commentary on 15 peer-reviewed journal articles, 5
conference papers, 2 national patents, 1 international patent, and 1 book chapter, with the 9
most significant publications included in the appendices. The scientific works focus on the
development, electrospinning, modification, and biomedical potential of various fibrous
materials. The first chapter discusses electrospinning of copolymers and polymer blends into
fibrous materials, aiming to optimize their water resistance, biodegradability, mechanical
properties, and absorption capacity. The scalability of needle-less electrospinning is particularly
highlighted as it allows bridging laboratory research with industrial production. The second
chapter explores advanced modification strategies of electrospun fibrous materials to meet
specific biomedical requirements, including improving antibacterial properties, enhancing cellmaterial
interactions, and optimizing drug release dynamics. Additionally, a novel predictive
numerical model is introduced to optimize fiber morphology based on solvent system
properties. The final chapter highlights the biomedical potential of electrospun materials,
demonstrating their applicability in bacterial filtration, customised wound care, sublingual drug
delivery using mucoadhesive patches, and targeted cancer therapy. This habilitation thesis
introduces innovative approaches to scalable production and functional modification of
electrospun fibrous materials, underscoring their significance as promising solutions to critical
challenges in modern biomedicine.
Description
Subject(s)
needle-less electrospinning, electrospun fibrous materials, modification strategies,
biomedical applications