Inkorporace hydrofilního/hydrofobního léčiva do biologicky odbouratelných nanovlákenných materiálů jako systémy pro dodávání léčiv

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dc.contributor.advisorChvojka Jiří, doc. Ing. Ph.D. :58591cs
dc.contributor.authorTomillo Amorós, Martacs
dc.contributor.refereeYalcinkaya Fatma, doc. MSc. Ph.D. :66770cs
dc.date.accessioned2025-02-19T10:12:36Z
dc.date.available2025-02-19T10:12:36Z
dc.date.committed20.5.2024cs
dc.date.defense30.1.2025cs
dc.date.submitted1.11.2022cs
dc.description.abstractTato diplomova prace zkouma porovnani technologii stejnosmerneho elektrickeho zvlaknovani (DCES) a stridaveho elektrickeho zvlaknovani (ACES) pro vyvoj nanovlakennych membran pouzivanych v systemech pro dodavani leciv (DDS). Studie se zameruje na inkorporaci kurkuminu, hydrofobni slouceniny zname pro sve protizanetlive a protinadorove vlastnosti, do nanovlaken z kyseliny polymlecne (PLA). Metody DCES a ACES byly hodnoceny z hlediska zvlaknitelnosti, morfologie vlaken, orientace a tepelnych vlastnosti pomoci diferencialni skenovaci kalorimetrie (DSC) a termogravimetricke analyzy (TGA). Vysledky ukazuji, ze obe metody DCES i ACES jsou schopne produkovat nanovlakna s pozadovanymi vlastnostmi, ale kazda metoda vykazuje odlisne vyhody. Navzdory pritomnosti nekterych defektu vlaken a neuplnemu rozpusteni kurkuminu u obou metod vykazovaly vysledne nanovlakenne membrany dobry potencial pro pouziti v systemech pro dodavani leciv. Tento vyzkum prispiva k pochopeni aplikovatelnosti technologie ACES v DDS a zduraznuje dulezitost optimalizace parametru electrospinningu pro efektivni integraci ucinnych farmaceutickych latek do biologicky odbouratelnych nanovlaken.cs
dc.description.abstractThis thesis investigates the comparative performance of Direct Current Electrospinning (DCES) and Alternating Current Electrospinning (ACES) technologies for the development of nanofibrous membranes used in drug delivery systems (DDS). The study focuses on the incorporation of curcumin, a hydrophobic compound known for its anti-inflammatory and anticancer properties, into Polylactic Acid (PLA) nanofibers. DCES and ACES methods were evaluated in terms of spinnability, fiber morphology, orientation, and thermal properties using Differential Scanning Calorimetry (DSC) and Thermogravimetric Analysis (TGA). The findings demonstrate that both DCES and ACES can produce nanofibers with desirable characteristics, but each method exhibits distinct advantages. Despite the presence of some fiber defects and incomplete curcumin dissolution in both methods, the resulting nanofibrous membranes displayed good potential for use in drug delivery applications. This research contributes to the understanding of ACES technology's applicability in DDS and highlights the importance of optimizing electrospinning parameters for the effective integration of active pharmaceutical ingredients into biodegradable nanofibers.en
dc.format43 p.cs
dc.identifier.urihttps://dspace.tul.cz/handle/15240/176726
dc.language.isoANcs
dc.subjectNanovlakenne membranycs
dc.subjectstejnosmerne elektricke zvlaknovani (DCES)cs
dc.subjectStridave elektricke zvlaknovani (ACES)cs
dc.subjectSystemy pro dodavani leciv (DDS)cs
dc.subjectKurkumincs
dc.subjectKyselina polymlecna (PLA)cs
dc.subjectMorfologie vlakencs
dc.subjectTepelne vlastnostics
dc.subjectDiferencialni skenovaci kalorimetrie (DSC)cs
dc.subjectTermogravimetricka analyza (TGA)cs
dc.subjectHydrofobni lecivacs
dc.subjectBiologicky odbouratelna nanovlakna.cs
dc.titleInkorporace hydrofilního/hydrofobního léčiva do biologicky odbouratelných nanovlákenných materiálů jako systémy pro dodávání léčivcs
dc.titleIncorporation of hydrophilic/hydrophobic drug into biodegradable nanofibrous materials as drug delivery systemsen
dc.typediplomová prácecs
local.degree.abbreviationNavazujícícs
local.identifier.authorT22000242cs
local.identifier.stag47312cs
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