Browsing by Author "Nováková, Martina"
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- ItemBeta3 adrenoceptors substitute the role of M 2 muscarinic receptor in coping with cold stress in the heart: Evidence from M 2KO mice(Technická Univerzita v Liberci, 2012) Beneš, Jan; Nováková, Martina; Rotková, Jana; Farár, Vladimír; Květňanský, Richard; Riljak, V.; Mysliveček, Jaromír B.We investigated the role of beta3-adrenoceptors (AR) in cold stress (1 or 7 days in cold) in animals lacking main cardioinhibitive receptors - M2 muscarinic receptors (M 2KO). There was no change in receptor number in the right ventricles. In the left ventricles, there was decrease in binding to all cardiostimulative receptors (beta1-, and beta2-AR) and increase in cardiodepressive receptors (beta3-AR) in unstressed KO in comparison to WT. The cold stress in WT animals resulted in decrease in binding to beta1- and beta2-AR (to 37%/35% after 1 day in cold and to 27%/28% after 7 days in cold) while beta3-AR were increased (to 216% of control) when 7 days cold was applied. MR were reduced to 46% and 58%, respectively. Gene expression of M2 MR in WT was not changed due to stress, while M3 was changed. The reaction of beta1- and beta2-AR (binding) to cold was similar in KO and WT animals, and beta3-AR in stressed KO animals did not change. Adenylyl cyclase activity was affected by beta3-agonist CL316243 in cold stressed WT animals but CL316243 had almost no effects on adenylyl cyclase activity in stressed KO. Nitric oxide activity (NOS) was not affected by BRL37344 (beta3-agonist) both in WT and KO animals. Similarly, the stress had no effects on NOS activity in WT animals and in KO animals. We conclude that the function of M2 MR is substituted by beta3-AR and that these effects are mediated via adenylyl cyclase rather than NOS. © Springer Science+Business Media, LLC 2011.
- ItemVolnočasové aktivity cizinců žijících na Jablonecku a Liberecku(Technická Univerzita v Liberci, 2011) Nováková, Martina; Kiryková, SimonaThe subject of the thesis "Leisure time activities of foreigners living in Liberec and Jablonec? is to find out what kind of leisure time activities are foreigners in this area interested in. Whether the demand of foreigners for these activities coincides with offer of the chosen organizations, whose activities focuses on the integration of foreigners into society in the Czech Republic.The first part deals with general information on foreigners in the Czechn Republic aimed at Liberec and Jablonec. It also states what are the causes of migration and the related problems and solutions of integration of foreigners into society. This section defines what generally leisure time is and leisure time related to foreigners. It further provides a list of selected major organizations that offer leisure time activities as a good solution for the integration of foreigners into Czech society.The second part will analyze the leisure time interests of foreigners and possibilities of free-time activities offered by the selected organizations to assist in the integration of foreigners in Liberec and Jablonec region. This will be done through interviews with a selected sample of foreigners and observations conducted during visits to these organizations.The conclusion of the thesis will be discussion of supply, demand and the overall availability of leisure time activities for foreigners in Liberec and Jablonec. Possible solutions will be given, that might help to offer more varied activities and usefulness of these activities to better integrate foreigners into society.Aim of the work: The Main aim of this thesis is to ascertain what kind of leisure time activities are foreigners of Liberec and Jablonec region interested in and to analyze them. Leisure time refers to the degree of integration and therefore we could call it a mirror of real integration. The aim is also to show that certain leisure-time activities can help foreigners integrate into the host society. Furthermore to detect if the demand for leisure time activities of foreigners living in Liberec and Jablonec is identical to the offerings of selected organizations.
- ItemVolnočasové aktivity cizinců žijících na Jablonecku a LibereckuNováková, Martina