Non-Woven PGA/PVA Fibrous Mesh as an Appropriate Scaffold for Chondrocyte Proliferation

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dc.contributor.authorRampichová, Michala
dc.contributor.authorKošťáková, Eva Kuželová
dc.contributor.authorFilová, Eva
dc.contributor.authorProsecká, E.
dc.contributor.authorPlencner, M.
dc.contributor.authorOčeretna, Larisa
dc.contributor.authorLytvynets, A.
dc.contributor.authorLukáš, David
dc.contributor.authorAmler, Evžen
dc.date.accessioned2016-07-08
dc.date.available2016-07-08
dc.date.issued2010
dc.description.abstractNon-woven textile mesh from polyglycolic acid (PGA) was found as a proper material for chondrocyte adhesion but worse for their proliferation. Neither hyaluronic acid nor chitosan nor polyvinyl alcohol (PVA) increased chondrocyte adhesion. However, chondrocyte proliferation suffered from acidic byproducts of PGA degradation. However, the addition of PVA and/or chitosan into a wet-laid non-woven textile mesh from PGA improved chondrocyte proliferation seeded in vitro on the PGA-based composite scaffold namely due to a diminished acidification of their microenvironment. This PVA/PGA composite mesh used in combination with a proper hydrogel minimized the negative effect of PGA degradation without dropping positive parameters of the PGA wet-laid non-woven textile mesh. In fact, presence of PVA and/or chitosan in the PGA-based wet-laid non-woven textile mesh even advanced the PGA-based wet-laid non-woven textile mesh for chondrocyte seeding and artificial cartilage production due to a positive effect of PVA in such a scaffold on chondrocyte proliferation.en
dc.formattext
dc.identifier.issn0862-8408
dc.identifier.scopus2-s2.0-78649744396
dc.identifier.urihttps://dspace.tul.cz/handle/15240/16576
dc.language.isoen
dc.publisherAcad Sciences Czech Republic, Inst Physiology
dc.relation.ispartofPhysiological Research
dc.sourcej-scopus
dc.sourcej-wok
dc.subjectPGAen
dc.subjectPVAen
dc.subjectNon-woven textileen
dc.subjectChondrocyteen
dc.subjectTissue engineeringen
dc.titleNon-Woven PGA/PVA Fibrous Mesh as an Appropriate Scaffold for Chondrocyte Proliferationen
dc.typearticle
local.accessopen access
local.citation.epage781
local.citation.spage773
local.departmentDepartment of nonwovens and nanofiber materials
local.facultyFaculty of Textile Engineering
local.fulltextyes
local.identifier.coden20406034
local.identifier.pubmedAcademy of Sciences of the Czech Republic [AV0Z50390703, AV0Z50390512]; Ministry of Education, Youth and Sports of the Czech Republic [2B06130, 1M0510]; Grant Agency of the Academy of Sciences [IAA500390702]; Czech Science Foundation [GA202/09/1151, P304/10/1307]; EU [214539]; Grant Agency of the Charles University [119209]
local.identifier.wokA1980KL32700014
local.notenefunguje RIV
local.relation.issue4-1
local.relation.volume59
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