Novel double-layered planar scaffold combining electrospun PCL fibers and PVA hydrogels with high shape integrity and water stability

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dc.contributor.authorKlíčová, Markéta
dc.contributor.authorKlápšťová, Andrea
dc.contributor.authorChvojka, Jiří
dc.contributor.authorKopřivová, Barbora
dc.contributor.authorJenčová, Věra
dc.contributor.authorHoráková, Jana
dc.date.accessioned2020-01-16T08:05:26Z
dc.date.available2020-01-16T08:05:26Z
dc.date.issued2020-03
dc.description.abstractNovel double-layered materials with different properties of each side were prepared via needleless electrospinning and compared in terms of morphology, wettability, adhesion and proliferation of mouse fibroblasts. The materials consist of hydrophilic poly(vinyl alcohol) fibers with low (PVA_L) or high (PVA_H) degree of hydrolysis, and hydrophobic poly(ε-caprolactone) (PCL) fibrous layer. Although the PVA_L fibers were fully dissolved following a water exposure, the shape of the scaffold was maintained due to water stable PCL layer. Exposing PVA_H based fibrous layer to water created a hydrogel-like structure with shape defined by the PCL layer. According to the MTT assay, the mouse fibroblasts seeded on the scaffold exhibited the greatest proliferative activity on the PCL fibers. These double-layered scaffolds with different features on each side are very promising for many novel medical applications such as wound dressing or abdominal adhesion prevention.cs
dc.format.extent4 stranycs
dc.identifier.WebofScienceResearcherIDA-8450-2018 Horáková, Jana
dc.identifier.doi10.1016/j.matlet.2019.127281
dc.identifier.issn0167577X
dc.identifier.orcid0000-0002-6924-800X Klápšťová, Andrea
dc.identifier.orcid0000-0001-8137-7878 Chvojka, Jiří
dc.identifier.orcid0000-0001-7391-9526 Jenčová, Věra
dc.identifier.orcid0000-0003-2926-0570 Horáková, Jana
dc.identifier.urihttps://dspace.tul.cz/handle/15240/154351
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0167577X19319135
dc.language.isocscs
dc.publisherElsevier B.V.
dc.relation.ispartofMaterials Letters
dc.subjectElectrospun fiberscs
dc.subjectElectrospinningcs
dc.subjectNanofiberscs
dc.titleNovel double-layered planar scaffold combining electrospun PCL fibers and PVA hydrogels with high shape integrity and water stabilitycs
local.article.number127281
local.identifier.publikace6987
local.relation.volume263
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