Effectiveness of Diverse Mesoporous Silica Nanoparticles as Potent Vehicles for the Drug L-DOPA

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dc.contributor.authorSwar, Sumita
dc.contributor.authorMáková, Veronika
dc.contributor.authorStibor, Ivan
dc.date.accessioned2019-10-29T07:53:41Z
dc.date.available2019-10-29T07:53:41Z
dc.date.issued2019
dc.description.abstractOur study was focused on the synthesis of selective mesoporous silica nanoparticles (MSNs: MCM-41, MCM-48, SBA-15, PHTS, MCF) that are widely studied for drug delivery. The resulting mesoporous surfaces were conveniently prepared making use of verified synthetic procedures. The MSNs thus obtained were characterized by Brunauer-Emmett-Teller (BET) analysis and scanning electron microscopy (SEM). The selected MSNs with various pore diameters and morphologies were examined to evaluate the capability of L-DOPA drug loading and release. L-DOPA is a well-known drug for Parkinson's disease. The L-DOPA drug loading and release profiles were measured by UV-VIS spectroscopy and SBA-15 was proved to be the most effective amongst all the different types of tested mesoporous silica materials as L-DOPA drug vehicle.cs
dc.format.extent15 strancs
dc.identifier.doi10.3390/ma12193202
dc.identifier.issn19961944
dc.identifier.orcid0000-0001-9719-6588 Máková, Veronika
dc.identifier.orcid0000-0002-8150-861X Swar, Sumita
dc.identifier.urihttps://dspace.tul.cz/handle/15240/154067
dc.identifier.urihttps://www.mdpi.com/1996-1944/12/19/3202
dc.language.isocscs
dc.publisherMDPI
dc.relation.ispartofMaterials
dc.subjectCharacterisationcs
dc.subjectDrug loading and releasecs
dc.subjectElectron microscopycs
dc.subjectMesoporous silicacs
dc.subjectNanoparticlescs
dc.subjectNitrogen adsorptioncs
dc.titleEffectiveness of Diverse Mesoporous Silica Nanoparticles as Potent Vehicles for the Drug L-DOPAcs
local.accessopen access
local.article.number3202
local.identifier.publikace6544
local.relation.issue19
local.relation.volume12
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