Detection and identification of engineered nanoparticles in exhaled breath condensate, blood serum, and urine of occupationally exposed subjects

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dc.contributor.authorLischková, Lucie
dc.contributor.authorPelclová, Daniela
dc.contributor.authorHlušička, Jiří
dc.contributor.authorNavrátil, Tomáš
dc.contributor.authorVlčková, Štěpánka
dc.contributor.authorFenclová, Zdenka
dc.contributor.authorDvořáčková, Štěpánka
dc.contributor.authorPopov, Alexey
dc.contributor.authorMichalcová, Alena
dc.contributor.authorMarek, Ivo
dc.contributor.authorMarek, Ivo
dc.contributor.authorMikuška, Pavel
dc.contributor.authorŽdímal, Vladimír
dc.contributor.authorKoštejn, Martin
dc.contributor.authorOndráček, Jakub
dc.contributor.authorSchwarz, Jaroslav
dc.contributor.authorZakharov, Sergey
dc.date.accessioned2019-10-02T07:20:46Z
dc.date.available2019-10-02T07:20:46Z
dc.date.issued2019-03
dc.description.abstractThe use of nanotechnology and the fields of application of nanomaterials are growing vastly, but the negative health effects on the exposed employees are not well studied. The standardized methods of monitoring of occupational exposure are still absent. The task of occupational physicians is to find the ways of evaluation of potential risks of exposure to engineered nanoparticles and to determine the biomarkers for early diagnostics and prevention of occupational diseases. The aim of our study was to detect and identify engineered nanoparticles in biological samples received from occupationally exposed subjects and to evaluate the association of findings with the results of external aerosol measurements on the workplace. The study cohort consisted of two groups of subjects. The first group was exposed to engineered nanoparticles containing mainly iron, manganese, and carbon compounds; the second group was exposed to the nanoparticles containing copper oxide. The post-shift biological samples (urine, blood serum, and exhaled breath condensate) were collected. The analysis was performed by transmission electron microscopy and energy-dispersive spectroscopy. The nanoparticles were detected in all the biological samples. The most common identified chemical elements were the biogenic ones (carbon, potassium, chlorine, oxygen), but the nanoparticles containing metals were identified in EBC, blood, and urine as well (gold, silver, copper, lanthanum, cerium, and tantalum). Our results demonstrate the possibility of detection of occupational exposure to the engineered nanoparticles in human biological fluids. Further studies are necessary to compare the pre-shift and post-shift burden of samples with engineered nanoparticles and to determine the magnitude of occupational exposure during the shift.cs
dc.format.extent13 strancs
dc.identifier.doi10.1007/s00706-019-2379-z
dc.identifier.urihttps://dspace.tul.cz/handle/15240/153818
dc.identifier.urihttps://link.springer.com/article/10.1007/s00706-019-2379-z
dc.language.isocscs
dc.publisherSPRINGER WIEN, SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA
dc.relation.ispartofMONATSHEFTE FUR CHEMIE
dc.subjectNanoparticlescs
dc.subjectOccupationally exposed subjectscs
dc.subjectDetectioncs
dc.subjectTransmission electron microscopycs
dc.titleDetection and identification of engineered nanoparticles in exhaled breath condensate, blood serum, and urine of occupationally exposed subjectscs
local.citation.epage523
local.citation.spage511
local.relation.issue3
local.relation.volume150
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