Three-Year Study of Markers of Oxidative Stress in Exhaled Breath Condensate in Workers Producing Nanocomposites, Extended by Plasma and Urine Analysis in Last Two Years

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dc.contributor.authorPelclova, Daniela
dc.contributor.authorZdimal, Vladimir
dc.contributor.authorKomarc, Martin
dc.contributor.authorSchwarz, Jaroslav
dc.contributor.authorOndracek, Jakub
dc.contributor.authorOndrackova, Lucie
dc.contributor.authorKostejn, Martin
dc.contributor.authorVlckova, Stepanka
dc.contributor.authorFenclova, Zdenka
dc.contributor.authorDvorackova, Stepanka
dc.contributor.authorLischkova, Lucie
dc.contributor.authorKlusackova, Pavlina
dc.contributor.authorKolesnikova, Viktoriia
dc.contributor.authorRossnerova, Andrea
dc.date.accessioned2021-04-22T08:07:19Z
dc.date.available2021-04-22T08:07:19Z
dc.date.issued2020
dc.description.abstractHuman data concerning exposure to nanoparticles are very limited, and biomarkers for monitoring exposure are urgently needed. In a follow-up of a 2016 study in a nanocomposites plant, in which only exhaled breath condensate (EBC) was examined, eight markers of oxidative stress were analyzed in three bodily fluids, i.e., EBC, plasma and urine, in both pre-shift and post-shift samples in 2017 and 2018. Aerosol exposures were monitored. Mass concentration in 2017 was 0.351 mg/m3 during machining, and 0.179 and 0.217 mg/m3 during machining and welding, respectively, in 2018. In number concentrations, nanoparticles formed 96%, 90% and 59%, respectively. In both years, pre-shift elevations of 50.0% in EBC, 37.5% in plasma and 6.25% in urine biomarkers were observed. Post-shift elevation reached 62.5% in EBC, 68.8% in plasma and 18.8% in urine samples. The same trend was observed in all biological fluids. Individual factors were responsible for the elevation of control subjects’ afternoon vs. morning markers in 2018; all were significantly lower compared to those of workers. Malondialdehyde levels were always acutely shifted, and 8-hydroxy-2-deoxyguanosine levels best showed chronic exposure effect. EBC and plasma analysis appear to be the ideal fluids for bio-monitoring of oxidative stress arising from engineered nanomaterials. Potential late effects need to be targeted and prevented, as there is a similarity of EBC findings in patients with silicosis and asbestosis.cs
dc.identifier.doi10.3390/nano10122440
dc.identifier.urihttps://dspace.tul.cz/handle/15240/159967
dc.identifier.urihttps://www.mdpi.com/2079-4991/10/12/2440
dc.language.isocscs
dc.publisherMDPI
dc.relation.ispartofNanomaterials 2020
dc.subjectnanoparticlescs
dc.subjectoxidative stresscs
dc.subjectbiomarkerscs
dc.subjectworkerscs
dc.subjectcontrolscs
dc.subjectexhaled breath condensatecs
dc.subjectplasmacs
dc.subjecturinecs
dc.titleThree-Year Study of Markers of Oxidative Stress in Exhaled Breath Condensate in Workers Producing Nanocomposites, Extended by Plasma and Urine Analysis in Last Two Yearscs
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