A comparative study between chemically modified and copper nanoparticle immobilized Nylon 6 films to explore their efficiency in fighting against two types of pathogenic bacteria

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dc.contributor.authorSwar, Sumita
dc.contributor.authorMáková, Veronika
dc.contributor.authorHoráková, Jana
dc.contributor.authorKejzlar, Pavel
dc.contributor.authorParma, Petr
dc.contributor.authorStibor, Ivan
dc.date.accessioned2020-03-02T07:23:26Z
dc.date.available2020-03-02T07:23:26Z
dc.date.issued2020-01-05
dc.description.abstractHospital-acquired infections (HAI) caused by pathogenic bacteria such as Pseudomonas aeruginosa and Staphylococcus aureus adversely affect public health due to their colonization and subsequent formation of a biofilm on medical devices. Various functionalized polymers including polyamides are commonly used in the biomedical industry aiming to resist bacterial infection as well as to ensure cytocompatibility of the used materials. The present study is focused on the extension of our previous work that developed a new approach to immobilize mPEG on an amine-activated Nylon 6 surface. Herein, we compare functionalized samples of Nylon 6 together with samples additionally containing copper nanoparticles (Cu NPs, size 40-60 nm) physisorbed on a modified surface. Modified samples were analyzed via different techniques including water contact angle measurements, atomic force microscopy and scanning electron microscopy associated with energy dispersive Xray spectroscopy. The copper functionalized samples showed high antibacterial efficacy against Gram-positive Staphylococcus aureus and Gram-negative Pseudomonas aeruginosa. Moreover, most of the prepared samples were cytocompatible.cs
dc.format.extent12 strancs
dc.identifier.WebofScienceResearcherIDA-8450-2018 Horáková, Jana
dc.identifier.doi0.1016/j.eurpolymj.2019.109392
dc.identifier.orcid0000-0002-8150-861X Swar, Sumita
dc.identifier.orcid0000-0001-9719-6588 Máková, Veronika
dc.identifier.orcid0000-0003-2926-0570 Horáková, Jana
dc.identifier.urihttps://dspace.tul.cz/handle/15240/154592
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0014305719318567
dc.language.isocscs
dc.relation.ispartofEUROPEAN POLYMER JOURNAL
dc.subjectNylon 6cs
dc.subjectPunctionalizationcs
dc.subjectCopper nanoparticlescs
dc.subjectAntibacterial activitycs
dc.subjectBacterial adhesioncs
dc.subjectCytocompatibilitycs
dc.titleA comparative study between chemically modified and copper nanoparticle immobilized Nylon 6 films to explore their efficiency in fighting against two types of pathogenic bacteriacs
local.article.numberUNSP 109392
local.identifier.publikace6855
local.identifier.publikace7665
local.relation.volume122
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