IRESite: the database of experimentally verified IRES structures (www.iresite.org)

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dc.contributor.authorMokrejš, Martin
dc.contributor.authorVopálenský, Václav
dc.contributor.authorKolenatý, Ondřej
dc.contributor.authorMašek, Tomáš
dc.contributor.authorFeketová, Zuzana
dc.contributor.authorSekyrová, Petra
dc.contributor.authorŠkaloudová, Barbora
dc.contributor.authorKříž, Vitězslav
dc.contributor.authorPospíšek, Martin
dc.date.accessioned2016-05-24
dc.date.available2016-05-24
dc.date.issued2006
dc.description.abstractIRESite is an exhaustive, manually annotated nonredundant relational database focused on the IRES elements (Internal Ribosome Entry Site) and containing information not available in the primary public databases. IRES elements were originally found in eukaryotic viruses hijacking initiation of translation of their host. Later on, they were also discovered in 5'-untranslated regions of some eukaryotic mRNA molecules. Currently, IRESite presents up to 92 biologically relevant aspects of every experiment, e. g. the nature of an IRES element, its functionality/defectivity, origin, size, sequence, structure, its relative position with respect to surrounding protein coding regions, positive/negative controls used in the experiment, the reporter genes used to monitor IRES activity, the measured reporter protein yields/activities, and references to original publications as well as cross-references to other databases, and also comments from submitters and our curators. Furthermore, the site presents the known similarities to rRNA sequences as well as RNA-protein interactions. Special care is given to the annotation of promoter-like regions. The annotated data in IRESite are bound to mostly complete, full-length mRNA, and whenever possible, accompanied by original plasmid vector sequences. New data can be submitted through the publicly available web-based interface at http://www.iresite.org and are curated by a team of lab-experienced biologists.en
dc.formattext
dc.identifier.doi10.1093/nar/gkj081
dc.identifier.issn0305-1048
dc.identifier.scopus2-s2.0-33644874187
dc.identifier.urihttps://dspace.tul.cz/handle/15240/16362
dc.identifier.urihttps://academic.oup.com/nar/article/34/suppl_1/D125/1133210
dc.language.isoen
dc.publisherOxford Univ Press
dc.publisherTechnická Univerzita v Libercics
dc.publisherTechnical university of Liberec, Czech Republicen
dc.relation.ispartofNucleic Acids Researchen
dc.sourcej-scopus
dc.sourcej-wok
dc.titleIRESite: the database of experimentally verified IRES structures (www.iresite.org)en
dc.typeArticle
local.accessοpen
local.citation.epageD130
local.citation.spageD125
local.departmentDepartment of Software Engineering
local.facultyFaculty of Mechatronics, Informatics and Interdisciplinary Studies
local.fulltextyes
local.identifier.pubmed16381829
local.identifier.stagRIV/00216208:11310/06:9873
local.identifier.wok239307700027
local.relation.volume34
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