Markers of Oxidative Stress in the Exhaled Breath Condensate of Workers Handling Nanocomposites

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dc.contributor.authorPelclová, Daniela
dc.contributor.authorŽdímal, Vladimír
dc.contributor.authorSchwarz, Jaroslav
dc.contributor.authorDvořáčková, Štěpánka
dc.contributor.authorKomarc, Martin
dc.contributor.authorOndráček, Jakub
dc.contributor.authorKoštejn, Martin
dc.contributor.authorKačer, Petr
dc.contributor.authorVlčková, Štěpánka
dc.contributor.authorFenclová, Zdenka
dc.contributor.authorPopov, Alexey
dc.contributor.authorLischková, Lucie
dc.contributor.authorZakharov, Sergey
dc.contributor.authorBello, Dhimiter
dc.date.accessioned2019-07-25T08:44:04Z
dc.date.available2019-07-25T08:44:04Z
dc.date.issued2019-08-10
dc.description.abstractResearchers in nanocomposite processing may inhale a variety of chemical agents, including nanoparticles. This study investigated airway oxidative stress status in the exhaled breath condensate (EBC). Nineteen employees (42.4 ± 11.4 y/o), working in nanocomposites research for 18.0 ± 10.3 years were examined pre-shift and post-shift on a random workday, together with nineteen controls (45.5 ± 11.7 y/o). Panels of oxidative stress biomarkers derived from lipids, nucleic acids, and proteins were analyzed in the EBC. Aerosol exposures were monitored during three major nanoparticle generation operations: smelting and welding (workshop 1) and nanocomposite machining (workshop 2) using a suite of real-time and integrated instruments. Mass concentrations during these operations were 0.120, 1.840, and 0.804 mg/m3 , respectively. Median particle number concentrations were 4.8 × 104 , 1.3 × 105 , and 5.4 × 105 particles/cm3 , respectively. Nanoparticles accounted for 95, 40, and 61%, respectively, with prevailing Fe and Mn. All markers of nucleic acid and protein oxidation, malondialdehyde, and aldehydes C6–C13 were elevated, already in the pre-shift samples relative to controls in both workshops. Significant post-shift elevations were documented in lipid oxidation markers. Significant associations were found between working in nanocomposite synthesis and EBC biomarkers. More research is needed to understand the contribution of nanoparticles from nanocomposite processing in inducing oxidative stress, relative to other co-exposures generated during welding, smelting, and secondary oxidation processes, in these workshops.cs
dc.format.extent19 strancs
dc.identifier.doi10.3390/nano8080611
dc.identifier.urihttps://dspace.tul.cz/handle/15240/152962
dc.identifier.urihttps://www.mdpi.com/2079-4991/8/8/611
dc.language.isocscs
dc.publisherMDPI
dc.relation.ispartofNanomaterials
dc.subjectnanoparticlescs
dc.subjectworkerscs
dc.subjectnanocompositescs
dc.subjectinhalationcs
dc.subjectexhaled breath condensatecs
dc.subjectoxidative stresscs
dc.subjectoccupational exposurecs
dc.titleMarkers of Oxidative Stress in the Exhaled Breath Condensate of Workers Handling Nanocompositescs
local.relation.issue8
local.relation.volume8
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