Electrospun vascular grafts fabricated from poly(L-lactide-co-epsilon-caprolactone) used as a bypass for the rabbit carotid artery

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dc.contributor.authorHoráková Janacs
dc.contributor.authorMikeš Petrcs
dc.contributor.authorLukáš Davidcs
dc.contributor.authorŠaman Alešcs
dc.contributor.authorJenčová Věracs
dc.contributor.authorKlápšťová Andreacs
dc.contributor.authorŠvarcová Terezacs
dc.contributor.authorAckermann Michalcs
dc.contributor.authorNovotný Vítcs
dc.contributor.authorKaláb Martincs
dc.contributor.authorLonský Vladimírcs
dc.contributor.authorBartoš Martincs
dc.contributor.authorRampichova Michalacs
dc.contributor.authorLitvinec Andrejcs
dc.contributor.authorKubíková Terezacs
dc.contributor.authorTomášek Petrcs
dc.contributor.authorTonar Zbyněkcs
dc.date.accessioned2018-09-25T12:20:19Z
dc.date.available2018-09-25T12:20:19Z
dc.date.issued2018cs
dc.description.abstractThe study involved the electrospinning of the copolymer poly(L-lactide-co-ε-caprolactone) (PLCL) into tubular grafts. The subsequent material characterization, including micro-computed tomography analysis, revealed a level of porosity of around 70%, with pore sizes of 9.34 ± 0.19 μm and fiber diameters of 5.58 ± 0.10 μm. Unlike fibrous polycaprolactone, the electrospun PLCL copolymer promoted fibroblast and endothelial cell adhesion and proliferation in vitro. Moreover, the regeneration of the vessel wall was detected following implantation and, after six months, the endothelialization of the lumen and the infiltration of arranged smooth muscle cells producing collagen was observed. However, the degradation rate was found to be accelerated in the rabbit animal model. The study was conducted under conditions that reflected the clinical requirements—the prostheses were sutured in the end-to-side fashion and the long-term end point of prosthesis healing was assessed. The regeneration of the vessel wall in terms of endothelialization, smooth cell infiltration and the presence of collagen fibers was observed after six months in vivo. A part of the grafts failed due to the rapid degradation rate of the PLCL copolymer.en
dc.format.extent16cs
dc.identifier.doi10.1088/1748-605X/aade9d
dc.identifier.issn1748-6041cs
dc.identifier.urihttps://dspace.tul.cz/handle/15240/32082
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/30177582/
dc.language.isoengcs
dc.publisherIOP Publishingcs
dc.relation.ispartofseries0cs
dc.relation.urihttp://iopscience.iop.org/article/10.1088/1748-605X/aade9dcs
dc.subjectvascular graftcs
dc.subjectelectrospinningcs
dc.subjectcopolymer poly-L-lactide-co-&epsics
dc.subject-caprolactonecs
dc.subjectrabbit animal modelcs
dc.titleElectrospun vascular grafts fabricated from poly(L-lactide-co-epsilon-caprolactone) used as a bypass for the rabbit carotid arteryen
local.identifier.publikace5559
local.relation.issue6cs
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