Ventilation Inhomogeneity and Bronchial Basement Membrane Changes in Chronic Neutrophilic Airway Inflammation
| dc.contributor.author | Koucký, Václav | |
| dc.contributor.author | Uhlík, Jiří | |
| dc.contributor.author | Hoňková, Lenka | |
| dc.contributor.author | Koucký, Miroslav | |
| dc.contributor.author | Doušová, Tereza | |
| dc.contributor.author | Pohunek, Petr | |
| dc.date.accessioned | 2020-03-27T16:12:08Z | |
| dc.date.available | 2020-03-27T16:12:08Z | |
| dc.date.issued | 2020-03-27 | |
| dc.description.abstract | Background: Bronchial epithelial reticular basement membrane (RBM) thickening occurs in diseases with both eosinophilic (allergic bronchial asthma [BA]) and neutrophilic (cystic fibrosis [CF] and primary ciliary dyskinesia [PCD]) chronic airway inflammation; however, the lung function and airway remodeling relation remains unclear. The aim of this study was to test whether ventilation inhomogeneity is related to RBM thickening. Methods: Multiple breath washout test, endobronchial biopsy, and BAL were performed in 24 children with CF, 11 with PCD, 15 with BA, and in 19 control subjects. Lung clearance index at 2.5% (1/40th) of starting nitrogen concentration (LCI2.5), RBM thickness, and lavage fluid cytology were quantified; their mutual associations were studied by using Spearman rank correlations (r). Results: In asthma, ventilation inhomogeneity (mean ± SD) was mild (LCI2.5, 9.3 ± 1.4 vs 7.9 ± 0.9 in control subjects; P = .0391), and the RBM thickened (5.26 ± 0.98 μm vs 3.12 ± 0.62 μm in control subjects; P < .0001). No relation between RBM thickness and ventilation inhomogeneity or lavage cytology was found. In CF and PCD, RBM thickness was similar to that in asthma (4.54 ± 0.66 μm and 5.27 ± 1.11 μm, respectively), but ventilation inhomogeneity was significantly higher (LCI2.5, 12.5 ± 2.4 and 11.8 ± 2.5). Both in CF and PCD, RBM thickness correlated with LCI2.5 (r = 0.594, P = .015; r = 0.821, P = .023). In PCD only, RBM thickness was also related to the number of neutrophils in lavage fluid (r = 0.821; P = .023). Conclusions: Lung function impairment in relation to RBM thickness was milder in BA than in CF and PCD. In asthma, ventilation inhomogeneity did not correlate with RBM thickness, whereas it did in CF and PCD. This outcome suggests a different structure-function relation in these diseases. | cs |
| dc.identifier.doi | 10.1016/j.chest.2019.10.023 | |
| dc.identifier.issn | 123692 | |
| dc.identifier.uri | https://dspace.tul.cz/handle/15240/154660 | |
| dc.identifier.uri | https://www.sciencedirect.com/science/article/abs/pii/S0012369219341881?via%3Dihub | |
| dc.language.iso | cs | cs |
| dc.publisher | Elsevier Inc | |
| dc.relation.ispartof | Chest 2020 | |
| dc.subject | airway remodeling | cs |
| dc.subject | bronchial asthma | cs |
| dc.subject | cystic fibrosis | cs |
| dc.subject | multiple breath washout test | cs |
| dc.subject | primary ciliary dyskinesia | cs |
| dc.subject | reticular basement membrane thickening | cs |
| dc.title | Ventilation Inhomogeneity and Bronchial Basement Membrane Changes in Chronic Neutrophilic Airway Inflammation | cs |
| dc.type | Conference Paper | |
| local.identifier.publikace | 7513 |