Prediction Potential of Serum miR-155 and miR-24 for Relapsing Early Breast Cancer

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dc.contributor.authorBašová Petracs
dc.contributor.authorPešta M.cs
dc.contributor.authorSochor Marekcs
dc.contributor.authorStopka Tomášcs
dc.date.accessioned2018-09-25T12:19:28Z
dc.date.available2018-09-25T12:19:28Z
dc.date.issued2017cs
dc.description.abstractOncogenic microRNAs (oncomiRs) accumulate in serum due to their increased stability and thus serve as biomarkers in breast cancer (BC) pathogenesis. Four oncogenic microRNAs (miR-155, miR-19a, miR-181b, and miR-24) and one tumor suppressor microRNA (let-7a) were shown to differentiate between high- and low-risk early breast cancer (EBC) and reflect the surgical tumor removal and adjuvant therapy. Here we applied the longitudinal multivariate data analyses to stochastically model the serum levels of each of the oncomiRs using the RT-PCR measurements in the EBC patients (N = 133) that were followed up 4 years after diagnosis. This study identifies that two of the studied oncomiRs, miR-155 and miR-24, are highly predictive of EBC relapse. Furthermore, combining the oncomiR level with Ki-67 expression further specifies the relapse probability. Our data move further the notion that oncomiRs in serum enable not only monitoring of EBC but also are a very useful tool for predicting relapse independently of any other currently analyzed characteristics in EBC patients. Our approach can be translated into medical practice to estimate individual relapse risk of EBC patients.en
dc.format.extent10cs
dc.identifier.doi10.3390/ijms18102116
dc.identifier.issn1422-0067cs
dc.identifier.urihttps://dspace.tul.cz/handle/15240/31960
dc.identifier.urihttps://www.mdpi.com/1422-0067/18/10/2116
dc.language.isoengcs
dc.publisherMDPI AGcs
dc.publisher.cityBaselcs
dc.relation.ispartofseries0cs
dc.relation.urihttp://www.mdpi.com/1422-0067/18/10/2116/pdfcs
dc.subjectBreast cancercs
dc.subjectKi-67cs
dc.subjectMicroRNAcs
dc.subjectMiR-155cs
dc.subjectMiR-24cs
dc.subjectRelapsecs
dc.titlePrediction Potential of Serum miR-155 and miR-24 for Relapsing Early Breast Canceren
dc.titlePrediction potential of serum MiR-155 and MiR-24 for relapsing early breast cancercs
local.citation.epage2116cs
local.citation.spage2116cs
local.identifier.publikace5431
local.relation.issue10cs
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