Fluorine polymer probes for magnetic resonance imaging: quo vadis?

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dc.contributor.authorJirák, Daniel
dc.contributor.authorGálisová, Andrea
dc.contributor.authorKolouchová, Kristýna
dc.contributor.authorBabuka, David
dc.contributor.authorHrubý, Martin
dc.date.accessioned2019-08-19T08:40:44Z
dc.date.available2019-08-19T08:40:44Z
dc.date.issued2019-02
dc.description.abstractOver the last few years, the development and relevance of F-19 magnetic resonance imaging (MRI) for use in clinical practice has emerged. MRI using fluorinated probes enables the achievement of a specific signal with high contrast in MRI images. However, to ensure sufficient sensitivity of F-19 MRI, fluorine probes with a high content of chemically equivalent fluorine atoms are required. The majority of F-19 MRI agents are perfluorocarbon emulsions, which have a broad range of applications in molecular imaging, although the content of fluorine atoms in these molecules is limited. In this review, we focus mainly on polymer probes that allow higher fluorine content and represent versatile platforms with properties tailorable to a plethora of biomedical in vivo applications. We discuss the chemical development, up to the first imaging applications, of these promising fluorine probes, including injectable polymers that form depots that are intended for possible use in cancer therapy.cs
dc.format.extent13 strancs
dc.identifier.WebofScienceResearcherIDH-6479-2014
dc.identifier.doi10.1007/s10334-018-0724-6
dc.identifier.urihttps://dspace.tul.cz/handle/15240/153225
dc.identifier.urihttps://link.springer.com/article/10.1007/s10334-018-0724-6
dc.language.isocscs
dc.relation.ispartofMAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
dc.subjectFluorinecs
dc.subjectMagnetic resonance imaging (MRI)cs
dc.subjectPolymercs
dc.subjectF-19 MRI probecs
dc.subjectMolecular imagingcs
dc.titleFluorine polymer probes for magnetic resonance imaging: quo vadis?cs
local.citation.epage185
local.citation.spage173
local.identifier.publikace6470
local.relation.issue1
local.relation.volume32
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