Synthesis and Comparative Biological Properties of Ag-PEG Nanoparticles with Tunable Morphologies from Janus to Multi-Core Shell Structure

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dc.contributor.authorPeterka, František
dc.contributor.authorXu, Mengda
dc.contributor.authorLiu, Jie
dc.contributor.authorXu, Xiankui
dc.contributor.authorLiu, Shanhu
dc.contributor.authorRen, Yanrong
dc.contributor.authorZhu, Xianfeng
dc.date.accessioned2021-04-26T07:50:33Z
dc.date.available2021-04-26T07:50:33Z
dc.date.issued2018-01-01
dc.description.abstractSilver nanoparticles synthesized with polymers as coating agents is an effective method to overcome their poor stability and aggregation in solution. Silver-polyethylene glycol (Ag-PEG) nanoparticles were synthesized with the thiol-functionalized polyethylene glycol (SH-PEA) as the coating, reducing and stabilizing agent. The UV irradiation time, polymer and silver nitrate concentration for the synthesis were investigated. The concentration of silver nitrate had significant effect on the morphology of Ag-PEG nanoparticles. When increasing the concentration of silver nitrate, SEM and TEM images showed that Ag-PEG nanoparticles changed from Janus to multi-core shell structure. Meanwhile, pure silver particles in the two hybrid nanoparticles presented spherical shape and had the similar size of 15 nm. The antibacterial activities and cytotoxicity of the two structural Ag-PEG nanoparticles were investigated to understand colloid morphology effect on the properties of AgNPs. The results of antibacterial activities showed that the two structural Ag-PEG nanoparticles exhibited strong antibacterial activities against Staphylococcus aureus, Escherichia coli and Bacillus subtilis. The Janus nanoparticles had larger minimal inhibitory concentration (MIC) and minimum bacterial concentration (MBC) values than the multi-core shell counterparts. The results of cytotoxicity showed the Janus Ag-PEG nanoparticles had lower toxicity than the multi-core shell nanoparticles.cs
dc.identifier.doi10.3390/ma11101787
dc.identifier.urihttps://dspace.tul.cz/handle/15240/159974
dc.identifier.urihttps://www.mdpi.com/1996-1944/11/10/1787
dc.language.isocscs
dc.publisherMDPI
dc.relation.ispartofMaterials 2018
dc.subjectsilver nanoparticlecs
dc.subjectPEGcs
dc.subjectJanus nanoparticlecs
dc.subjectmuli-core shell nanoparticlecs
dc.subjectantibacterial activitycs
dc.subjectcytotoxicitycs
dc.titleSynthesis and Comparative Biological Properties of Ag-PEG Nanoparticles with Tunable Morphologies from Janus to Multi-Core Shell Structurecs
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