Comprehensive assessment of electrospun scaffolds hemocompatibility

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dc.contributor.authorHoráková Janacs
dc.contributor.authorMikeš Petrcs
dc.contributor.authorŠaman Alešcs
dc.contributor.authorPavlíková Terezacs
dc.contributor.authorJenčová Věracs
dc.contributor.authorSuchý Tomášcs
dc.contributor.authorHeczková Bohdanacs
dc.contributor.authorJakůbková Šárkacs
dc.contributor.authorJiroušová Jaroslavacs
dc.contributor.authorProcházková Renatacs
dc.date.accessioned2018-09-25T12:10:40Z
dc.date.available2018-09-25T12:10:40Z
dc.date.issued2018cs
dc.description.abstractBiodegradable polyesters, namely polycaprolactone (PCL) and copolymer of polylactide and polycaprolactone (PLCL) were electrospun into various fibrous structures and their hemocompatibility was evaluated in vitro. Firstly, hemolytic effect was evaluated upon incubation with diluted whole blood. The results showed that the degree of hemolysis depended on chemical composition and fibrous morphology. Electrospun polycaprolactone induced slight degree of hemolysis depending on its molecular weight and fibrous morphology; copolymer PLCL did not cause detectable hemolysis. The influence of coagulation pathways was examined by measurement of coagulation times. It was showed that intrinsic coagulation pathway assessed by activated partial thromboplastin time (APTT) was moderately accelerated after incubation with PCL and prolonged after incubation with copolymer PLCL. Extrinsic activation of coagulation tested by prothrombin time (PT) was slightly accelerated after incubation with all tested electrospun samples. Thrombogenicity assessment of fibrous samples revealed high thrombogenic properties of fibrous materials that was comparable to high degree of collagen thrombogenicity. The level of platelet activation was dependent on chemical composition and surface morphology of tested materials.en
dc.format.extent10cs
dc.identifier.doi10.1016/j.msec.2017.05.011
dc.identifier.issn0928-4931cs
dc.identifier.urihttps://dspace.tul.cz/handle/15240/30690
dc.identifier.urihttp://www.sciencedirect.com/science/article/pii/S0928493116307913
dc.language.isoengcs
dc.publisherElsevier BVcs
dc.publisher.cityNetherlandscs
dc.relation.ispartofMaterials Science and Engineering: C
dc.relation.ispartofseries0cs
dc.relation.urihttp://www.sciencedirect.com/science/article/pii/S0928493116307913cs
dc.subjectBlood compatibilitycs
dc.subjectCollagencs
dc.subjectCopolymer of polylactide and polycaprolactonecs
dc.subjectFibrous scaffoldscs
dc.subjectPolycaprolactonecs
dc.titleComprehensive assessment of electrospun scaffolds hemocompatibilityen
dc.titleComprehensive assessment of electrospun scaffolds hemocompatibilitycs
local.citation.epage330-335cs
local.citation.spage330-335cs
local.identifier.publikace4140
local.identifier.wok414886400037en
local.relation.issueJANcs
local.relation.volume82
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