Inhibition of acetylcholinesterase in different structures of the rat brain following soman intoxication pretreated with huperzine A

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dc.contributor.authorBajgar, Jiří
dc.contributor.authorHájek, Petr
dc.contributor.authorKarasová, Jana
dc.contributor.authorSlížová, Dáša
dc.contributor.authorKrs, Otakar
dc.contributor.authorKuča, Kamil
dc.contributor.authorJun, Daniel
dc.contributor.authorFusek, Josef
dc.contributor.authorČapek, Lukáš
dc.date.accessioned2016-07-08
dc.date.available2016-07-08
dc.date.issued2007
dc.description.abstractAcetylcholinesterase (AChE) activities in different brain parts were determined quantitatively in rats treated with huperzine A, soman, and huperzine A followed by soman, using histochemical and biochemical methods. Following soman intoxication ( 1.2 x LD50, i.m.), AChE activity was decreased to 30-80% of control values depending on the brain structure. The most sensitive area was the frontal cortex and the most relatively resistant was ncl.ruber. Huperzine A treatment only caused a change in AChE activity varying from 70 to 100% of control values. In rats pretreated with huperzine A and intoxicated with soman, AChE activity was significantly higher than that observed after soman. In these animals, survival of rats pretreated with huperzine was observed while the mortality of unpretreated animals was near to 80%. The results suggest that huperzine A is good candidate for further study for clinical use as a prophylactic drug against nerve agent poisoning.en
dc.formattext
dc.identifier.doi10.3390/i8111165
dc.identifier.issn1422-0067
dc.identifier.scopus2-s2.0-36849067932
dc.identifier.urihttps://dspace.tul.cz/handle/15240/16640
dc.identifier.urihttps://www.mdpi.com/1422-0067/8/11/1165
dc.language.isoen
dc.publisherMdpi Ag
dc.relation.ispartofInternational Journal Of Molecular Sciences
dc.sourcej-scopus
dc.sourcej-wok
dc.subjectacetylcholinesteraseen
dc.subjectrat brain partsen
dc.subjectsomanen
dc.subjectHuperzine Aen
dc.subjectpretreatmenten
dc.titleInhibition of acetylcholinesterase in different structures of the rat brain following soman intoxication pretreated with huperzine Aen
dc.typearticle
local.accessopen access
local.citation.epage1176
local.citation.spage1165
local.departmentDepartment of Engineering Mechanics
local.facultyFaculty of Mechanical Engineering
local.fulltextyes
local.identifier.wok251238700007
local.notenefunguje RIV
local.relation.issue10-1
local.relation.volume8
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