Thin-Layer Hydroxyapatite Deposition on a Nanofiber Surface Stimulates Mesenchymal Stem Cell Proliferation and Their Differentiation into Osteoblasts

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dc.contributor.authorProsecká, Eva
dc.contributor.authorBuzgo, Matej
dc.contributor.authorRampichová, Michala
dc.contributor.authorKocourek, Tomáš
dc.contributor.authorKochová, Petra
dc.contributor.authorVysloužilová, Lucie
dc.contributor.authorTvrdík, Daniel
dc.contributor.authorJelínek, Miroslav
dc.contributor.authorLukáš, David
dc.contributor.authorAmler, Evžen
dc.date.accessioned2016-05-24
dc.date.available2016-05-24
dc.date.issued2012
dc.description.abstractPulsed laser deposition was proved as a suitable method for hydroxyapatite (HA) coating of coaxial poly-epsilon-caprolactone/polyvinylalcohol (PCL/PVA) nanofibers. The fibrous morphology of PCL/PVA nanofibers was preserved, if the nanofiber scaffold was coated with thin layers of HA (200 nm and 400 nm). Increasing thickness of HA, however, resulted in a gradual loss of fibrous character. In addition, biomechanical properties were improved after HA deposition on PCL/PVA nanofibers as the value of Young's moduli of elasticity significantly increased. Clearly, thin-layer hydroxyapatite deposition on a nanofiber surface stimulated mesenchymal stem cell viability and their differentiation into osteoblasts. The optimal depth of HA was 800 nm.en
dc.description.sponsorshipAcademy of Sciences of the Czech Republic [AV0Z50390703, AV0Z50390512]; Ministry of Education, Youth, and Sports of the Czech Republic [2B06130]; Grant Agency of the Academy of Sciences [IAA500390702]; Grant Agency of the Charles University [96610, 97110, 330611, 384311, 164010]; Grant Agency of the Czech Republic [P304/10/1307, 109/09/P226]; Ministry of Education of the Czech Republic [ME 10145]; Internal Grant Agency Ministry of Health of the Czech Republic [NT12156-5/2011]; Czech Science Foundation [GA202/09/1151]
dc.formattext
dc.identifier.doi10.1155/2012/428503
dc.identifier.issn1110-7243
dc.identifier.scopus2-s2.0-84858126426
dc.identifier.urihttps://dspace.tul.cz/handle/15240/16409
dc.language.isoen
dc.publisherHindawi Publishing Corporation
dc.publisherTechnická Univerzita v Libercics
dc.publisherTechnical university of Liberec, Czech Republicen
dc.relation.ispartofJournal Of Biomedicine And Biotechnologyen
dc.sourcej-scopus
dc.sourcej-wok
dc.titleThin-Layer Hydroxyapatite Deposition on a Nanofiber Surface Stimulates Mesenchymal Stem Cell Proliferation and Their Differentiation into Osteoblastsen
dc.typeArticle
local.accessopen
local.departmentDepartment of Nonwovens and Nanofibrous Materials
local.facultyFaculty of Textile Engineering
local.fulltextyes
local.identifier.stagRIV/49777513:23520/12:43915509
local.identifier.wok301378600001
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