History of Cyclodextrin Nanosponges

Simple item page
dc.contributor.authorKrabicová Ilonacs
dc.contributor.authorAppleton Silvia Luciacs
dc.contributor.authorTannous Mariacs
dc.contributor.authorHoti Gjylijecs
dc.contributor.authorCaldera Fabriziocs
dc.contributor.authorRubin Pedrazzo Albertocs
dc.contributor.authorCecone Claudiocs
dc.contributor.authorCavalli Robertacs
dc.contributor.authorTrotta Francescocs
dc.date.accessioned2020-06-08T09:51:57Z
dc.date.available18-52-2020en
dc.date.available2020-06-08T09:51:57Z
dc.date.issued2020cs
dc.date.updated18-01-2020en
dc.description.abstractNowadays, research in the field of nanotechnology and nanomedicine has become increasingly predominant, focusing on the manipulation and development of materials on a nanometer scale. Polysaccharides have often been used as they are safe, non-toxic, hydrophilic, biodegradable and are low cost. Among them, starch derivatives and, in particular, cyclodextrin-based nanosponges (CD NSs) have recently emerged due to the outstanding properties attributable to their peculiar structure. In fact, alongside the common polysaccharide features, such as the presence of tunable functional groups and their ability to interact with biological tissues, thus giving rise to bioadhesion, which is particularly useful in drug delivery, what makes CD NSs unique is their three-dimensional network made up of crosslinked cyclodextrin units. The name “nanosponge” appeared for the first time in the 1990s due to their nanoporous, sponge-like structure and responded to the need to overcome the limitations of native cyclodextrins (CDs), particularly their water solubility and inability to encapsulate charged and large molecules efficiently. Since CD NSs were introduced, efforts have been made over the years to understand their mechanism of action and their capability to host molecules with low or high molecular weight, charged, hydrophobic or hydrophilic by changing the type of cyclodextrin, crosslinker and degree of crosslinking used. They enabled great advances to be made in various fields such as agroscience, pharmaceutical, biomedical and biotechnological sectors, and NS research is far from reaching its conclusion. This review gives an overview of CD NS research, focusing on the origin and key points of the historical development in the last 50 years, progressing from relatively simple crosslinked networks in the 1960s to today’s multifunctional polymers. The approach adopted in writing the present study consisted in exploring the historical evolution of NSs in order to understand their role today, and imagine their future.en
dc.format.extent23cs
dc.identifier.doi10.3390/polym12051122
dc.identifier.issn2073-4360cs
dc.identifier.urihttps://dspace.tul.cz/handle/15240/156839
dc.identifier.urihttps://www.mdpi.com/2073-4360/12/5/1122
dc.language.isoengcs
dc.publisherMDPI AGcs
dc.relation.ispartofPolymersen
dc.relation.ispartofseries1cs
dc.relation.urihttps://www.mdpi.com/2073-4360/12/5/1122cs
dc.subjecthistorycs
dc.subjectcyclodextrin nanospongecs
dc.subjectcrosslinked polymercs
dc.titleHistory of Cyclodextrin Nanospongesen
dc.titleHistory of Cyclodextrin Nanospongescs
local.identifier.publikace7674
local.relation.issue5cs
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
History of Cyclodextrin Nanosponges.pdf
Size:
1.8 MB
Format:
Adobe Portable Document Format
Description:
článek
Download
Collections