Biochemical and biophysical aspects of collagen nanostructure in the extracellular matrix

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dc.contributor.authorKoláčná, Lucie
dc.contributor.authorBakešová, J.
dc.contributor.authorVarga, Ferdinand
dc.contributor.authorKošťáková Kuželova, Eva
dc.contributor.authorPlánka, Ladislav
dc.contributor.authorNečas, Alois
dc.contributor.authorLukáš, David
dc.contributor.authorAmler, Evžen
dc.contributor.authorPelouch, Václav
dc.date.accessioned2016-05-24
dc.date.available2016-05-24
dc.date.issued2007
dc.description.abstractECM is composed of different collagenous and non-collagenous proteins. Collagen nanofibers play a dominant role in maintaining the biological and structural integrity of various tissues and organs, including bone, skin, tendon, blood vessels, and cartilage. Artificial collagen nanofibers are increasingly significant in numerous tissue engineering applications and seem to be ideal scaffolds for cell growth and proliferation. The modern tissue engineering task is to develop three-dimensional scaffolds of appropriate biological and biomechanical properties, at the same time mimicking the natural extracellular matrix and promoting tissue regeneration. Furthermore, it should be biodegradable, bioresorbable and non-inflammatory, should provide sufficient nutrient supply and have appropriate viscoelasticity and strength. Attributed to collagen features mentioned above, collagen fibers represent an obvious appropriate material for tissue engineering scaffolds. The aim of this minireview is, besides encapsulation of the basic biochemical and biophysical properties of collagen, to summarize the most promising modern methods and technologies for production of collagen nanofibers and scaffolds for artificial tissue development. © 2007 Institute of Physiology, v. v. i., Academy of Sciences of the Czech Republic.en
dc.formattext
dc.identifier.issn0862-8408
dc.identifier.scopus2-s2.0-38549148896
dc.identifier.urihttps://dspace.tul.cz/handle/15240/16417
dc.language.isoen
dc.publisherTechnická Univerzita v Libercics
dc.publisherTechnical university of Liberec, Czech Republicen
dc.relation.ispartofPhysiological Researchen
dc.sourcej-scopus
dc.sourcej-wok
dc.subjectBiomechanical propertiesen
dc.subjectCollagenen
dc.subjectExtracellular matrixen
dc.subjectNanofibersen
dc.subjectScaffolden
dc.titleBiochemical and biophysical aspects of collagen nanostructure in the extracellular matrixen
dc.typeArticle
local.accessopen
local.citation.epage60
local.citation.spage51
local.departmentDepartment of nonwovens and nanofiber materials
local.facultyFaculty of Textile Engineering
local.fulltextyes
local.identifier.codenPHRSE
local.identifier.pubmed17552894
local.identifier.stagRIV/00216224:14110/07:00027066
local.identifier.wok252436800008
local.relation.issue1
local.relation.volume56
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