Browsing by Author "Suchý Tomáš"

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    A comparison of the centrifugal force spinning and electrospinning of collagen under different conditions
    (TANGER Ltd., 2016-01-01) Hlavatá Jana; Suchý Tomáš; Šupová Monika; Pokorný Marek; Košťáková Eva
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    Comprehensive assessment of electrospun scaffolds hemocompatibility
    (Elsevier BV, 2018-01-01) Horáková Jana; Mikeš Petr; Šaman Aleš; Pavlíková Tereza; Jenčová Věra; Suchý Tomáš; Heczková Bohdana; Jakůbková Šárka; Jiroušová Jaroslava; Procházková Renata
    Biodegradable polyesters, namely polycaprolactone (PCL) and copolymer of polylactide and polycaprolactone (PLCL) were electrospun into various fibrous structures and their hemocompatibility was evaluated in vitro. Firstly, hemolytic effect was evaluated upon incubation with diluted whole blood. The results showed that the degree of hemolysis depended on chemical composition and fibrous morphology. Electrospun polycaprolactone induced slight degree of hemolysis depending on its molecular weight and fibrous morphology; copolymer PLCL did not cause detectable hemolysis. The influence of coagulation pathways was examined by measurement of coagulation times. It was showed that intrinsic coagulation pathway assessed by activated partial thromboplastin time (APTT) was moderately accelerated after incubation with PCL and prolonged after incubation with copolymer PLCL. Extrinsic activation of coagulation tested by prothrombin time (PT) was slightly accelerated after incubation with all tested electrospun samples. Thrombogenicity assessment of fibrous samples revealed high thrombogenic properties of fibrous materials that was comparable to high degree of collagen thrombogenicity. The level of platelet activation was dependent on chemical composition and surface morphology of tested materials.
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    Delayed donor reactions to blood donations – anonymous electronic survey
    (Česká lékařská společnost J.E. Purkyně, 2018-01-01) Papoušek Petr; Královská Z.; Suchý Tomáš; Procházková Renata
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    Delayed Donor Reactions to Blood Donations 8211 Anonymous Electronic Survey
    (2018-01-01) Procházková Renata; Královská Zdeňka; Suchý Tomáš; Papoušek Petr
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    The effect of ethylene oxide sterilization on electrospun vascular grafts made from biodegradable polyesters
    (ELSEVIER SCIENCE BV, 2018-01-01) Horáková Jana; Mikeš Petr; Šaman Aleš; Jenčová Věra; Klápšťová Andrea; Švarcová Tereza; Ackermann Michal; Novotný Vít; Suchý Tomáš; Lukáš David
    The study describes the detailed examination of the effect of ethylene oxide sterilization on electrospun scaffolds constructed from biodegradable polyesters. Different fibrous layers fabricated from polycaprolactone (PCL) and a copolymer consisting of polylactide and polycaprolactone (PLCL) were investigated for the determination of their mechanical properties, degradation rates and interaction with fibroblasts. It was discovered that the sterilization procedure influenced the mechanical properties of the electrospun PLCL copolymer scaffold to the greatest extent. No effect of ethylene oxide sterilization on degradation behavior was observed. However, a delayed fibroblast proliferation rate was noticed with concern to the ethylene oxide sterilized samples compared to the ethanol sterilization of the materials.
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    Generating standardized image data for testing and calibrating quantification of volumes, surfaces, lengths, and object counts in fibrous and porous materials using X-ray microtomography
    (John Wiley & Sons Inc., 2018-01-01) Bartoš Martin; Tomášek Petr; Malečková Anna; Jiřík Miroslav; Kural Tomáš; Horáková Jana; Lukáš David; Suchý Tomáš; Kochová Petra; Hubálek-Kalbáčová Marie; Králíčková Milena; Tonar Zbyněk
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    Hemocompatibility of nanofibrous materials
    (2016-01-01) Kaláb Martin; Jakůbková Šárka; Mikeš Petr; Heczková Bohdana; Horáková Jana; Suchý Tomáš; Procházková Renata; Lonský Vladimír; Jiroušová Jaroslava; Pavlíková Tereza
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    Hemocompatibility of nanofibrous materials and its presentation
    (2016-01-01) Horáková Jana; Mikeš Petr; Suchý Tomáš
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    Storing red cells at non-standard temperature
    (2020-01-01) Papoušek Petr; Škodová Sabina; Řehořová Lenka; Procházková Renata; Turek P.; Suchý Tomáš; Andrýs C.
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    Thrombogenicity of biodegradable polyesters
    (2015-01-01) Horáková Jana; Kryšková Petra; Durasová Zuzana; Jenčová Věra; Suchý Tomáš; Jakůbková Šárka; Procházková Renata