Browsing by Author "Pálek Richard"

Now showing 1 - 12 of 12
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    Antiadhesive Nanofibers for Novel Applications in Gastrointestinal Surgery
    (TANGER Ltd., 2021) Klápšťová Andrea; Krejčík Michal; Müllerová Jana; Erben Jakub; Rosendorf Jáchym; Pálek Richard; Liška Václav; Horáková Jana
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    Antiadhesive Nanofibers for Novel Applications in Gastrointestinal Surgery
    (TANGER Ltd., 2021) Klíčová Markéta; Klápšťová Andrea; Krejčík Michal; Műllerová Senta; Erben Jakub; Rosendorf Jáchym; Pálek Richard; Liška Václav; Horáková Jana
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    Biodegradable nanofibrous materials for fortification of gastrointestinal anastomoses
    (TANGER Ltd., 2021) Műllerová Senta; Klíčová Markéta; Klápšťová Andrea; Petržílková Michaela; Šatínský Dalibor; Raabová Hedvika; Rosendorf Jáchym; Pálek Richard; Liška Václav
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    Biodegradable polyester-based materials for novel biomedical applications
    (České vysoké učení technické v Praze, 2021) Klíčová Markéta; Hujer Jan; Erben Jakub; Liška Václav; Rosendorf Jáchym; Pálek Richard; Calamari Elisabeth; Feng Di; Novak Richard; Ingber Donald; Horáková Jana
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    Double-layered Nanofibrous Patch for Prevention of Anastomotic Leakage and Peritoneal Adhesions, Experimental Study
    (In Vivo, 2021) Rosendorf Jáchym; Klíčová Markéta; Červenková Lenka; Pálek Richard; Horáková Jana; Klápšťová Andrea; Hošek Petr; Moulisová Vladimíra; Bednář Lukáš; Tégl Václav; Brzoň Ondřej; Tonar Zbyněk; Třeška Vladislav; Lukáš David; Liška Václav
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    Histological mapping of porcine carotid arteries - An animal model for the assessment of artificial conduits suitable for coronary bypass grafting in humans
    (Elsevier BV, 2020) Tomášek Petr; Tonar Zbyněk; Grajciarová Martina; Kural Tomáš; Turek Daniel; Horáková Jana; Pálek Richard; Eberlová Lada; Králíčková Milena; Liška Václav
    Background: Using animal models in experimental medicine requires mapping of their anatomical variability. Porcine common carotid arteries (CCA) are often preferred for the preclinical testing of vascular grafts due to their anatomical and physiological similarity to human small-diameter arteries. Comparing the microscopic structure of animal model organs to their human counterparts reveals the benefits and limitations of translational medicine. Methods: Using quantitative histology and stereology, we performed an extensive mapping of the regional proximodistal differences in the fractions of elastin, collagen, and smooth muscle actin as well as the intima-media and wall thicknesses among 404 segments (every 1 cm) of porcine CCAs collected from male and female pigs (n = 21). We also compared the microscopic structure of porcine CCAs with segments of human coronary arteries and one of the preferred arterial conduits used for the coronary artery bypass grafting (CABG), namely, the internal thoracic artery (ITA) (n = 21 human cadavers). Results: The results showed that the histological structure of left and right porcine CCA can be considered equivalent, provided that gross anatomical variations of the regular branching patterns are excluded. The proximal elastic carotid (51.2% elastin, 4.2% collagen, and 37.2% actin) transitioned to more muscular middle segments (23.5% elastin, 4.9% collagen, 54.3% actin) at the range of 2-3 centimeters and then to even more muscular distal segments (17.2% elastin, 4.9% collagen, 64.0% actin). The resulting morphometric data set shows the biological variability of the artery and is made available for biomechanical modeling and for performing a power analysis and calculating the minimum number of samples per group when planning further experiments with this widely used large animal model. Conclusions: Comparison of porcine carotids with human coronary arteries and ITA revealed the benefits and the limitations of using porcine CCAs as a valid model for testing bioengineered small-diameter CABG vascular conduits. Morphometry of human coronary arteries and ITA provided more realistic data for tailoring multilayered artificial vascular prostheses and the ranges of values within which the conduits should be tested in the future. Despite their limitations, porcine CCAs remain a widely used and well-characterized large animal model that is available for a variety of experiments in vascular surgery.
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    Hydrophobic ultrafine hyaluronic acid nanofibers
    (Avestia Publishing, 2019) Klíčová Markéta; Klápšťová Andrea; Voleský Lukáš; Horáková Jana; Rosendorf Jáchym; Pálek Richard; Liška Václav
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    Nanofibrous materials for prevention of postoperative adhesions
    (České vysoké učení technické, 2019) Klíčová Markéta; Horáková Jana; Klápšťová Andrea; Krejčík Michal; Rosendorf Jáchym; Pálek Richard; Liška Václav
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    Planar polymeric nanofibrous patches for sealing the gastrointestinal anastomoses
    (Technická univerzita v Liberci, 2019) Oulehlová Zuzana; Klíčová Markéta; Horáková Jana; Klápšťová Andrea; Liška Václav; Rosendorf Jáchym; Pálek Richard; Červenková Lenka
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    Plasma treatment of hydrophilic nanofibrous surfaces
    (České vysoké učení technické, 2018) Klíčová Markéta; Horáková Jana; Voleský Lukáš; Klápšťová Andrea; Jirkovec Radek; Liška Václav; Rosendorf Jáchym; Pálek Richard
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    Polyester-based nanofibers for novel applications in regenerative medicine
    (České vysoké učení technické v Praze, 2020) Klíčová Markéta; Erben Jakub; Klápšťová Andrea; Liška Václav; Rosendorf Jáchym; Pálek Richard; Ingber Donald; Novak Richard; Calamari Elisabeth; Feng Di; Horáková Jana
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    Reinforcement of Colonic Anastomosis with Improved Ultrafine Nanofibrous Patch: Experiment on Pig
    (MDPI AG, 2021) Rosendorf Jáchym; Klíčová Markéta; Červenková Lenka; Horáková Jana; Klápšťová Andrea; Hošek Petr; Pálek Richard; Ševčík Jan; Polák Robert; Třeška Vladislav; Chvojka Jiří; Liška Václav