Browsing by Author "Melichar Bohuslav"
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- ItemAssociation of the combined parameters including the frequency of primary cilia, CD8 tumor infiltrating lymphocytes and PD-1 expression with the outcome in intestinal cancer(Zerbinis Medical Publications, 2017) Dvořák Josef; Nikolov DH; Dušek Ladislav; Filipová Alžběta; Richter Igor; Buka D.; Ryska Aleš; Mokrý Jaroslav; Filip Stanislav; Melichar Bohuslav; Buchler Tomáš; Abrahámová Jitka
- ItemThe changes of tumour vascular endothelial growth factor expression after neoadjuvant chemoradiation in patients with rectal adenocarcinoma(Termedia Sp. z.o.o., 2017) Buka D.; Dvořák Josef; Sitorová Veronika; Sirák Igor; Vobořil René; Melichar Bohuslav; Richter IgorAim of the study: The aim was to examine the effects of neoadjuvant chemoradiotherapy on VEGF expression in patients with locally advanced rectal cancer. Materials and methods: A total of 53 patients with locally advanced rectal cancer were retrospectively studied. Neoadjuvant treatment comprised external beam radiation (50.4 Gy/28 fractions) with continuous infusion of 5-fluorouracil. Four to 6 weeks after the chemoradiotherapy, the patients underwent surgical resection. Immunohistochemistry was performed to assess VEGF expression in the pretreatment biopsies and in resected specimens. Results: Resection with microscopic residual tumour (R1) was performed in two patients while in the remaining 51 patients radical resection with microscopically negative margins (R0) was possible. Downstaging after preoperative chemoradiotherapy was observed in 34 patients (64%). After chemoradiotherapy 24 patients (45%) had decreased VEGF expression, in 20 patients (38%) there was no change, and in two patients it was not possible to assess the dynamics of VEGF expression due to pathologic complete response after chemoradiotherapy. The five-year overall survival (OS) rate was 56% (95% CI: 43–70%). Although the median OS was 2.5 times shorter in patients who experienced decreased VEGF expression during therapy, this difference did not reach statistical significance. VEGF expression was not significant in Cox regression analysis or log-rank test. VEGF expression decreased after neoadjuvant chemoradiotherapy in most patients with rectal adenocarcinoma examined. This decrease was associated with a trend of inferior prognosis. Conclusions: VEGF expression decreased after neoadjuvant chemoradiotherapy in most patients examined. This decrease was associated with a trend of inferior prognosis.
- ItemInteraction of PD1, CD8 tumor infiltrating lymphocytes and primary cilia in clear cell renal cell carcinoma(2018) Dvořák Josef; Rosová Blanka; Filipová Alžběta; Dušek Ladislav; Hadži Nikolov D.; Richter Igor; Rozsypalová Aneta; Melichar Bohuslav; Buchler Tomáš; Abrahámová Jitka
- ItemInterakce mezi anti-VEGF léčbou a protinádorovou imunitou jako potenciální léčebná strategie kolorektálního karcinomu(2019) Buka D.; Dvořák Josef; Richter Igor; Škrobánek Pavel; Buchler Tomáš; Melichar Bohuslav
- ItemNegative prognostic significance of primary cilia, CD8 tumor infiltrating lymphocytes and PD1 cells expression in clear cell renal cancer(Zerbinis Medical Publications, 2020) Rozsypalová Aneta; Rosová Blanka; Filipová Alžběta; Hadži Nikolov D.; Renata Chloupková; Richter Igor; Prokš Jan; Zachoval Roman; Radoslav Matěj; Melichar Bohuslav; Buchler Tomáš; Dvořák Josef
- ItemPatients with metastatic renal cell carcinoma treated with cabozantinib in the Czech Republic: analysis of four cancer centers(Palacky University Olomouc, 2020) Richter Igor; Poprach Alexandr; Zemánková Anežka; Buchler Tomáš; Bartoš Jiří; Šámal Vladimír; Rozsypalová Aneta; Dvořák Josef; Brom Ondřej; Melichar Bohuslav; Studentová Hana
- ItemPrincipal Relationship of Primary Lines, Pd-1 And Cd8 Tumor Influencing Lymphocytes At the Adenokarcinom of the Tensile Wood And Colorate(2017) Dvořák Josef; Hadži Nikolov D.; Dušek L.; Filipová A.; Richter Igor; Buka D.; Ryška A.; Melichar Bohuslav; Buchler Tomáš; Abrahámová Jitka
- ItemPrognostic significance of primary cilia in relation to selected parameters of the tumor microenvironment of clear cell renal cell carcinoma(2020) Rozsypalová Aneta; Rosová Blanka; Filipová Alžběta; Hadži Nikolov D.; Chloupková Renata; Richter Igor; Prokš Jan; Radoslav Matěj; Zachoval Roman; Melichar Bohuslav; Buchler Tomáš; Dvořák Josef
- ItemSarcopenia in Metastatic Renal Cell Carcinoma Patients Treated with Cabozantinib(2020) Buchler Tomáš; Kopecká Marie; Zemánková Anežka; Wiesnerová Markéta; Strecková Eva; Rozsypalová Aneta; Melichar Bohuslav; Poprach Alexandr; Richter Igor
- ItemSimulations of centriole of polarized centrozome as a monopole antenna in immune and viral synapses(2018) Dvořák Josef; Melichar Bohuslav; Filipová A.; Grimová Jana; Rozsypalová Aneta; Buka D.; Vobořil René; Zapletal R.; Buchler Tomáš; Richter Igor