Browsing by Author "Máková, Veronika"
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- Item(1S,2S)-Cyclohexane-1,2-diamine-based Organosilane Fibres as a Powerful Tool Against Pathogenic Bacteria(MDPI, 2020-01) Máková, Veronika; Holubová, Barbora; Tetour, David; Brus, Jiří; Řezanka, Michal; Rysová, Miroslava; Hodačová, JanaAn urgent need to find an effective solution to bacterial resistance is pushing worldwide research for highly effective means against this threat. Newly prepared hybrid organosilane fibres consisting of a (1S,2S)-cyclohexane-1,2-diamine derivative, interconnected in the fibre network via covalent bonds, were fully characterised via different techniques, including FTIR, TGA-FTIR, SEM-EDS, and solid-state NMR. Fibrous samples were successfully tested against two types of pathogenic bacterial strains, namely Staphylococcus aureus, and Pseudomonas aeruginosa. The obtained results, showing >99.9% inhibition against Staphylococcus aureus and Pseudomonas aeruginosa in direct contact compared to the control, may help particularly in case of infections, where there is an urgent need to treat the infection in direct contact. From this point of view, the above-mentioned fibrous material may find application in wound healing. Moreover, this new material has a positive impact on fibroblasts viability.
- Item(1S,2S)‐Cyclohexane‐1,2‐diamine‐based Organosilane Fibres as a Powerful Tool Against Pathogenic Bacteria(MDPI, 2020) Máková, Veronika; Holubová, Barbora; Tetour, David; Brus, Jiří; Řezanka, Michal; Rysová, Miroslava; Hodačová, JanaAn urgent need to find an effective solution to bacterial resistance is pushing worldwide research for highly effective means against this threat. Newly prepared hybrid organosilane fibres consisting of a (1S,2S)-cyclohexane-1,2-diamine derivative, interconnected in the fibre network via covalent bonds, were fully characterised via different techniques, including FTIR, TGA-FTIR, SEM-EDS, and solid-state NMR. Fibrous samples were successfully tested against two types of pathogenic bacterial strains, namely Staphylococcus aureus, and Pseudomonas aeruginosa. The obtained results, showing >99.9% inhibition against Staphylococcus aureus and Pseudomonas aeruginosa in direct contact compared to the control, may help particularly in case of infections, where there is an urgent need to treat the infection in direct contact. From this point of view, the above-mentioned fibrous material may find application in wound healing. Moreover, this new material has a positive impact on fibroblasts viability.
- ItemA comparative study between chemically modified and copper nanoparticle immobilized Nylon 6 films to explore their efficiency in fighting against two types of pathogenic bacteria(2020-01-05) Swar, Sumita; Máková, Veronika; Horáková, Jana; Kejzlar, Pavel; Parma, Petr; Stibor, IvanHospital-acquired infections (HAI) caused by pathogenic bacteria such as Pseudomonas aeruginosa and Staphylococcus aureus adversely affect public health due to their colonization and subsequent formation of a biofilm on medical devices. Various functionalized polymers including polyamides are commonly used in the biomedical industry aiming to resist bacterial infection as well as to ensure cytocompatibility of the used materials. The present study is focused on the extension of our previous work that developed a new approach to immobilize mPEG on an amine-activated Nylon 6 surface. Herein, we compare functionalized samples of Nylon 6 together with samples additionally containing copper nanoparticles (Cu NPs, size 40-60 nm) physisorbed on a modified surface. Modified samples were analyzed via different techniques including water contact angle measurements, atomic force microscopy and scanning electron microscopy associated with energy dispersive Xray spectroscopy. The copper functionalized samples showed high antibacterial efficacy against Gram-positive Staphylococcus aureus and Gram-negative Pseudomonas aeruginosa. Moreover, most of the prepared samples were cytocompatible.
- ItemEffectiveness of Diverse Mesoporous Silica Nanoparticles as Potent Vehicles for the Drug L-DOPA(MDPI, 2019) Swar, Sumita; Máková, Veronika; Stibor, IvanOur study was focused on the synthesis of selective mesoporous silica nanoparticles (MSNs: MCM-41, MCM-48, SBA-15, PHTS, MCF) that are widely studied for drug delivery. The resulting mesoporous surfaces were conveniently prepared making use of verified synthetic procedures. The MSNs thus obtained were characterized by Brunauer-Emmett-Teller (BET) analysis and scanning electron microscopy (SEM). The selected MSNs with various pore diameters and morphologies were examined to evaluate the capability of L-DOPA drug loading and release. L-DOPA is a well-known drug for Parkinson's disease. The L-DOPA drug loading and release profiles were measured by UV-VIS spectroscopy and SBA-15 was proved to be the most effective amongst all the different types of tested mesoporous silica materials as L-DOPA drug vehicle.
- ItemHybrid organosilane materials and its application in material engineering(2021) Máková, VeronikaNanomaterials together with nanotechnologies bring everyday challenges to modern material science and allow scientists worldwide to develop completely new types of unique materials having extraordinary properties. Although interest in hybrid organic-inorganic organosilane fibrous nanomaterials is rising, there is no complete review and/or literature covering and completing the knowledge regarding this highly promissive research area. Todate, only a few solitary research papers have been published regarding this topic. Herein, organo-mono-silylated and organo-bis-silylated precursors were studied in detail. In addition, the proposed synthetic strategies together with their outcomes were successfully applied for the formation of organosilane fibers made of the above-mentioned hybrid precursors. The techniques of self-assembly, drawing, and in particular electrospinning, are widely discussed in the theoretical part of this thesis. The electrospinning technique was then directly used for the formation of organosilane fibers. The results related to this topic are present in the second part of this thesis. Moreover, they are supported by recently published articles, which are added to and described in the supplementary part of this habilitation thesis. The presented findings are closely connected to the application potential and show the unique and promising prospects of these hybrid organosilane fibers in various fields of modern material science covering a wide range of industries, including the textile industry, and particularly everyday life.
- ItemNovel chapter in hybrid materials: One-pot synthesis of purely organosilane fibers(Elsevier Ltd, 2020-03) Holubová, Barbora; Máková, Veronika; Müllerová, Jana; Brus, Jiří; Havlíčková, Kristýna; Jenčová, Věra; Michalcová, Alena; Kulhánková, Johana; Řezanka, MichalDespite the extensive literature on organosilane hybrid materials, there are very few reports on the preparation of purely organosilane non-woven fibrous mats. Nevertheless, their use in various application fields may be of great importance regarding the global issue of polymer fibers and the toxicity of other compounds used so far in the composite polymer-organosilane fiber-manufacturing process. The greatest obstacle seems to be the supposed difficulty in the polymerization of organosilanes in a spinnable polymeric solution. In this work, we report the one-pot synthesis of electrospun organosilane fibers without any kinds of surfactants, low-molecular-weight polymeric gelators or spinnable polymers. The purely organosilane fibrous mats were prepared only via a suitable adjustment of the sol-gel processing parameters and were successfully produced an industrial electrospinning device, promising possible fabrication on a large scale. Moreover, the use of two differently-structured model benzene functionalized organoalkoxysilanes proves the possibility of designing a molecularly engineered material tailored to specific applications. These organosilane fibrous mats seem to be promising in various application fields, such as reusable catalysts, adsorption or conducting membranes or as novel biomaterials. This latter of these areas was preliminarily studied herein.
- ItemPhotochemically catalysed polymerisation of 3-trimethoxysilylpropyl methacrylate containing silver, copper and zinc ions(University of Chemistry and Technology, Faculty of Environmental Technology, 2018) Máková, Veronika; Špína, Michal; Müllerová, Jana; Exnar, PetrPhoto curable organic-inorganic monomers are currently generating much interest in many research groups worldwide due to their unique properties leading to a wide range of applications including electronics, energetics, medicine, etc. One of them, 3-trimethoxysilylpropylmethacrylate belongs to the class of such monomers having a wide range of relatively good mechanical, chemical and physical properties. Moreover, this monomer can be cured by different processes including heat treatment and light. Photochemically catalysed polymerisation of sol prepared from 3-trimethoxysilylpropylmethacrylate hybrid monomer and titanium tetraisopropoxide containing silver, copper and zinc ions was tested with two commercially available photoinitiators, a Darocur 1173 and an Irgacure 819. The aim of this study was to propose conditions for the effective polymerisation process leading to the maximal conversion of double bonds present in the organic part of the hybrid monomer and observe the potential effect of the ions. Particularly the copper ions by themselves and/or in combination with silver ions inside the hybrid matrix may influence the speed and conversion degree of the photochemically catalysed polymerisation processes. © 2018 University of Chemistry and Technology, Faculty of Environmental Technology.
- ItemPovrchová modifikace cévních náhrad připravených z polykaprolaktonu(Evropská mezinárodní konference Biomateriály, 2018) Máková, Veronika