Browsing by Author "Litvinec Andrej"
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- ItemElectrospun vascular grafts fabricated from poly(L-lactide-co-epsilon-caprolactone) used as a bypass for the rabbit carotid artery(IOP Publishing, 2018) Horáková Jana; Mikeš Petr; Lukáš David; Šaman Aleš; Jenčová Věra; Klápšťová Andrea; Švarcová Tereza; Ackermann Michal; Novotný Vít; Kaláb Martin; Lonský Vladimír; Bartoš Martin; Rampichova Michala; Litvinec Andrej; Kubíková Tereza; Tomášek Petr; Tonar ZbyněkThe study involved the electrospinning of the copolymer poly(L-lactide-co-ε-caprolactone) (PLCL) into tubular grafts. The subsequent material characterization, including micro-computed tomography analysis, revealed a level of porosity of around 70%, with pore sizes of 9.34 ± 0.19 μm and fiber diameters of 5.58 ± 0.10 μm. Unlike fibrous polycaprolactone, the electrospun PLCL copolymer promoted fibroblast and endothelial cell adhesion and proliferation in vitro. Moreover, the regeneration of the vessel wall was detected following implantation and, after six months, the endothelialization of the lumen and the infiltration of arranged smooth muscle cells producing collagen was observed. However, the degradation rate was found to be accelerated in the rabbit animal model. The study was conducted under conditions that reflected the clinical requirements—the prostheses were sutured in the end-to-side fashion and the long-term end point of prosthesis healing was assessed. The regeneration of the vessel wall in terms of endothelialization, smooth cell infiltration and the presence of collagen fibers was observed after six months in vivo. A part of the grafts failed due to the rapid degradation rate of the PLCL copolymer.
- ItemHydrogel Containing Anti-CD44-Labeled Microparticles, Guide Bone Tissue Formation in Osteochondral Defects in Rabbits(MDPI AG, 2020) Filova Eva; Tonar Zbyněk; Lukášová Věra; Buzgo Matej; Litvinec Andrej; Rampichova Michala; Beznoska Jiří; Plencner Martin; Staffa Andrea; Dankova J; Soural Miroslav; Chvojka Jiří; Malečková Anna; Králíčková Milena; Amler Evžen
- ItemThe combination of nanofibrous and microfibrous materials for enhancement of cell infiltration and in vivo bone tissue formation(IOP Publishing, 2018) Rampichova Michala; Chvojka Jiří; Jenčová Věra; Kubíková Tereza; Tonar Zbyněk; Erben Jakub; Buzgo Matej; Dankova J; Litvinec Andrej; Vocetková K; Plencner Martin; Prosecka Eva; Sovková V; Lukášová Věra; Králíčková Milena; Lukáš David; Amler Evžen