Browsing by Author "Kuča, Kamil"
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- ItemInhibition of acetylcholinesterase in different structures of the rat brain following soman intoxication pretreated with huperzine A(Mdpi Ag, 2007) Bajgar, Jiří; Hájek, Petr; Karasová, Jana; Slížová, Dáša; Krs, Otakar; Kuča, Kamil; Jun, Daniel; Fusek, Josef; Čapek, LukášAcetylcholinesterase (AChE) activities in different brain parts were determined quantitatively in rats treated with huperzine A, soman, and huperzine A followed by soman, using histochemical and biochemical methods. Following soman intoxication ( 1.2 x LD50, i.m.), AChE activity was decreased to 30-80% of control values depending on the brain structure. The most sensitive area was the frontal cortex and the most relatively resistant was ncl.ruber. Huperzine A treatment only caused a change in AChE activity varying from 70 to 100% of control values. In rats pretreated with huperzine A and intoxicated with soman, AChE activity was significantly higher than that observed after soman. In these animals, survival of rats pretreated with huperzine was observed while the mortality of unpretreated animals was near to 80%. The results suggest that huperzine A is good candidate for further study for clinical use as a prophylactic drug against nerve agent poisoning.
- ItemTreatment costs of Parkinson’s disease in Central Europe(Technická Univerzita v Liberci, ) Marešová, Petra; Klímová, Blanka; Vališ, Martin; Kuča, Kamil; Mohelská, Hana; Ekonomická fakultaThe aim of the study is to describe current values of direct costs of Parkinson’s disease in western and central Europe in comparison with other available data in order to illustrate the development of the treatment costs of Parkinson’s disease (PD) on the public sector. In this research study Drummond’s methodology is used for the specification of costs. The costs are divided into two categories. The first category consists of the costs of creation and running of health care program and these costs are perceived as the used sources. The costs are calculated on the basis of the reviews of the studies from the European countries, but also on the basis of authors’ own survey in the University Hospital of Hradec Kralove conducted among 510 patients in the period of 2011-to the third quarter of 2015. Within this study the direct costs among 510 patients at the University Hospital of Hradec Kralove were explored in the period of 2011- to the third quarter of 2015. These costs included neurological examination, CT screening, blood collection, hospitalization, and drugs. The total direct costs of patient per year reached 2,032 €. The survey showed that the underpinning of patients with PD was beneficial from the costs point of view because the costs on the outpatient care were much lower in comparison with the inpatient care. In addition, patients released from the hospital are usually transferred to the establishments with subsequent care, for example into hospices, because family care due to its complexity is impossible.