Browsing by Author "Jakůbková Šárka"
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- ItemComprehensive assessment of electrospun scaffolds hemocompatibility(Elsevier BV, 2018) Horáková Jana; Mikeš Petr; Šaman Aleš; Pavlíková Tereza; Jenčová Věra; Suchý Tomáš; Heczková Bohdana; Jakůbková Šárka; Jiroušová Jaroslava; Procházková RenataBiodegradable polyesters, namely polycaprolactone (PCL) and copolymer of polylactide and polycaprolactone (PLCL) were electrospun into various fibrous structures and their hemocompatibility was evaluated in vitro. Firstly, hemolytic effect was evaluated upon incubation with diluted whole blood. The results showed that the degree of hemolysis depended on chemical composition and fibrous morphology. Electrospun polycaprolactone induced slight degree of hemolysis depending on its molecular weight and fibrous morphology; copolymer PLCL did not cause detectable hemolysis. The influence of coagulation pathways was examined by measurement of coagulation times. It was showed that intrinsic coagulation pathway assessed by activated partial thromboplastin time (APTT) was moderately accelerated after incubation with PCL and prolonged after incubation with copolymer PLCL. Extrinsic activation of coagulation tested by prothrombin time (PT) was slightly accelerated after incubation with all tested electrospun samples. Thrombogenicity assessment of fibrous samples revealed high thrombogenic properties of fibrous materials that was comparable to high degree of collagen thrombogenicity. The level of platelet activation was dependent on chemical composition and surface morphology of tested materials.
- ItemHemocompatibility of nanofibrous materials(2016) Kaláb Martin; Jakůbková Šárka; Mikeš Petr; Heczková Bohdana; Horáková Jana; Suchý Tomáš; Procházková Renata; Lonský Vladimír; Jiroušová Jaroslava; Pavlíková Tereza
- ItemPlatelet interaction with nano-and microfibrous materials for the tissue engineering(2017) Procházková Renata; Jakůbková Šárka; Horáková Jana; Jenčová Věra
- ItemThrombogenicity of biodegradable polyesters(2015) Horáková Jana; Kryšková Petra; Durasová Zuzana; Jenčová Věra; Suchý Tomáš; Jakůbková Šárka; Procházková Renata