Browsing by Author "Šaman Aleš"
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- ItemAnalysis of small diameter vascular grafts made from biodegradable polyesters(2015-01-01) Horáková Jana; Novák Patrik; Klápšťová Andrea; Pavlíková Tereza; Šaman Aleš; Ackermann Michal; Mikeš Petr
- ItemArtificial muscle(2015-01-01) Lukáš David; Šaman Aleš; Zálešáková Denisa; Chvojka Jiří; Klápšťová Andrea
- ItemAssessment of cell adhesion on electrospun polycaprolactone scaffold sterilized by ethylene oxide(2017-01-01) Horáková Jana; Pavlíková Tereza; Šaman Aleš; Klápšťová Andrea; Mikeš Petr; Jenčová Věra
- ItemComparison and characterization of different polyester nano/micro fibres for use in tissue engineering applications(2021-01-01) Mikeš Petr; Horáková Jana; Šaman Aleš; Vejsadová Lucie; Jenčová Věra
- ItemComparison and characterization of different polyester nano/micro fibres for use in tissue engineering applications(2019-01-01) Mikeš Petr; Horáková Jana; Šaman Aleš; Vejsadová Lucie; Topham Paul; Jenčová Věra
- ItemComparison of electrospun fibrous materials made from polycaprolactone (pcl) and polylactide-polycaprolactone copolymer (plc) for small diameter blood vessel tissue engineering(2015-01-01) Klápšťová Andrea; Šaman Aleš; Jenčová Věra; Horáková Jana; Blažková Lenka; Mikeš Petr; Ackermann Michal
- ItemComparison of the Well Known Spinning And Electrospinning Methods for Polyvinyl Alcohol(FOART, s.r.o., 2016-01-01) Blažková Lenka; Horáková Jana; Kalous Tomáš; Pelcl Martin; Strnadová Kateřina; Šaman Aleš; Chvojka Jiří; Novák Patrik; Hlavatá Jana
- ItemComprehensive assessment of electrospun scaffolds hemocompatibility(Elsevier BV, 2018-01-01) Horáková Jana; Mikeš Petr; Šaman Aleš; Pavlíková Tereza; Jenčová Věra; Suchý Tomáš; Heczková Bohdana; Jakůbková Šárka; Jiroušová Jaroslava; Procházková RenataBiodegradable polyesters, namely polycaprolactone (PCL) and copolymer of polylactide and polycaprolactone (PLCL) were electrospun into various fibrous structures and their hemocompatibility was evaluated in vitro. Firstly, hemolytic effect was evaluated upon incubation with diluted whole blood. The results showed that the degree of hemolysis depended on chemical composition and fibrous morphology. Electrospun polycaprolactone induced slight degree of hemolysis depending on its molecular weight and fibrous morphology; copolymer PLCL did not cause detectable hemolysis. The influence of coagulation pathways was examined by measurement of coagulation times. It was showed that intrinsic coagulation pathway assessed by activated partial thromboplastin time (APTT) was moderately accelerated after incubation with PCL and prolonged after incubation with copolymer PLCL. Extrinsic activation of coagulation tested by prothrombin time (PT) was slightly accelerated after incubation with all tested electrospun samples. Thrombogenicity assessment of fibrous samples revealed high thrombogenic properties of fibrous materials that was comparable to high degree of collagen thrombogenicity. The level of platelet activation was dependent on chemical composition and surface morphology of tested materials.
- ItemDegradation behavior of electrospun resorbable polyester nano/micro fibrous materials(2017-01-01) Jenčová Věra; Mikeš Petr; Horáková Jana; Chvojka Jiří; Klápšťová Andrea; Šaman Aleš; Lukáš David; Novotný Vít
- ItemDegradation behavior of polyester micro / nano fibrous materials(2017-01-01) Jenčová Věra; Mikeš Petr; Horáková Jana; Klápšťová Andrea; Novotný Vít; Běhálek Luboš; Šaman Aleš
- ItemDevelopment and optimisation of nanofibrous film containing active solution(2017-01-01) Mikeš Petr; Chvojka Jiří; Šaman Aleš; Lukáš David; Zálešáková Denisa; Štěpánová Petra; Horáková Jana; Jenčová Věra
- ItemDEVELOPMENT OF FIBROUS IMPLANT FOR THE TREATMENT OF GLAUCOMA(TANGER spol. s r.o., 2016-01-01) Klápšťová Andrea; Horáková Jana; Vršínská Klára; Šaman Aleš; Shynkarenko Andrii; Lukáš David
- ItemDevelopment of material for selected typs ofmolecules(2017-01-01) Lukáš David; Mikeš Petr; Šaman Aleš; Chvojka Jiří; Nevyhoštěný Stanislav; Jirkovec Radek; Štěpánová Petra
- ItemThe double encapsulation of bioactive molecules usinkg the electrospraying method with the possibility of the drug controlled relase(2015-01-01) Šaman Aleš; Horáková Jana; Mikeš Petr; Klápšťová Andrea; Jenčová Věra
- ItemEectrospraying Aliphatic Polyesters for Drug Delivery Systems(Scientific Publishing House, 2015-01-01) Šaman Aleš; Horáková Jana; Strnadová Kateřina; Mikeš Petr
- ItemThe effect of ethylene oxide sterilization on electrospun vascular grafts made from biodegradable polyesters(ELSEVIER SCIENCE BV, 2018-01-01) Horáková Jana; Mikeš Petr; Šaman Aleš; Jenčová Věra; Klápšťová Andrea; Švarcová Tereza; Ackermann Michal; Novotný Vít; Suchý Tomáš; Lukáš DavidThe study describes the detailed examination of the effect of ethylene oxide sterilization on electrospun scaffolds constructed from biodegradable polyesters. Different fibrous layers fabricated from polycaprolactone (PCL) and a copolymer consisting of polylactide and polycaprolactone (PLCL) were investigated for the determination of their mechanical properties, degradation rates and interaction with fibroblasts. It was discovered that the sterilization procedure influenced the mechanical properties of the electrospun PLCL copolymer scaffold to the greatest extent. No effect of ethylene oxide sterilization on degradation behavior was observed. However, a delayed fibroblast proliferation rate was noticed with concern to the ethylene oxide sterilized samples compared to the ethanol sterilization of the materials.
- ItemElectrospun Polylactide-Polycaprolactone Copolymer for Vascular Tissue Engineering(Scientific Publishing House Akapit, 2015-01-01) Horáková Jana; Mikeš Petr; Šaman Aleš; Ackermann Michal
- ItemElectrospun vascular grafts fabricated from poly(L-lactide-co-epsilon-caprolactone) used as a bypass for the rabbit carotid artery(IOP Publishing, 2018-01-01) Horáková Jana; Mikeš Petr; Lukáš David; Šaman Aleš; Jenčová Věra; Klápšťová Andrea; Švarcová Tereza; Ackermann Michal; Novotný Vít; Kaláb Martin; Lonský Vladimír; Bartoš Martin; Rampichova Michala; Litvinec Andrej; Kubíková Tereza; Tomášek Petr; Tonar ZbyněkThe study involved the electrospinning of the copolymer poly(L-lactide-co-ε-caprolactone) (PLCL) into tubular grafts. The subsequent material characterization, including micro-computed tomography analysis, revealed a level of porosity of around 70%, with pore sizes of 9.34 ± 0.19 μm and fiber diameters of 5.58 ± 0.10 μm. Unlike fibrous polycaprolactone, the electrospun PLCL copolymer promoted fibroblast and endothelial cell adhesion and proliferation in vitro. Moreover, the regeneration of the vessel wall was detected following implantation and, after six months, the endothelialization of the lumen and the infiltration of arranged smooth muscle cells producing collagen was observed. However, the degradation rate was found to be accelerated in the rabbit animal model. The study was conducted under conditions that reflected the clinical requirements—the prostheses were sutured in the end-to-side fashion and the long-term end point of prosthesis healing was assessed. The regeneration of the vessel wall in terms of endothelialization, smooth cell infiltration and the presence of collagen fibers was observed after six months in vivo. A part of the grafts failed due to the rapid degradation rate of the PLCL copolymer.
- ItemELEKTROSTATICKÉ ZVLÁKŇOVÁNÍ POLYESTERŮ: POROVNÁNÍ POLYMERNÍCH VLÁKENNÝCH STRUKTUR A JEJICH VLIV NA PROLIFERACI FIBROBLASTŮ(Technical University of Liberec, 2016-01-01) Šaman Aleš; Vejsadová Lucie; Horáková Jana; Jenčová Věra; Mikeš Petr
- ItemFunctionalization of Nano and Microfibrous Vascular Grafts by Nitric Oxide(Technical University in Liberec, 2015-01-01) Šaman Aleš; Strnadová Kateřina; Horáková Jana; Mikeš Petr