(1S,2S)-Cyclohexane-1,2-diamine-based Organosilane Fibres as a Powerful Tool Against Pathogenic Bacteria

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dc.contributor.author Máková, Veronika
dc.contributor.author Holubová, Barbora
dc.contributor.author Tetour, David
dc.contributor.author Brus, Jiří
dc.contributor.author Řezanka, Michal
dc.contributor.author Rysová, Miroslava
dc.contributor.author Hodačová, Jana
dc.date.accessioned 2020-04-15T06:52:38Z
dc.date.available 2020-04-15T06:52:38Z
dc.date.issued 2020-01
dc.identifier.uri https://dspace.tul.cz/handle/15240/154733
dc.identifier.uri https://www.mdpi.com/2073-4360/12/1/206
dc.description.abstract An urgent need to find an effective solution to bacterial resistance is pushing worldwide research for highly effective means against this threat. Newly prepared hybrid organosilane fibres consisting of a (1S,2S)-cyclohexane-1,2-diamine derivative, interconnected in the fibre network via covalent bonds, were fully characterised via different techniques, including FTIR, TGA-FTIR, SEM-EDS, and solid-state NMR. Fibrous samples were successfully tested against two types of pathogenic bacterial strains, namely Staphylococcus aureus, and Pseudomonas aeruginosa. The obtained results, showing >99.9% inhibition against Staphylococcus aureus and Pseudomonas aeruginosa in direct contact compared to the control, may help particularly in case of infections, where there is an urgent need to treat the infection in direct contact. From this point of view, the above-mentioned fibrous material may find application in wound healing. Moreover, this new material has a positive impact on fibroblasts viability. cs
dc.format.extent 12 stran cs
dc.language.iso cs cs
dc.publisher MDPI
dc.relation.ispartof Polymers 2020
dc.subject organic-inorganic hybrids cs
dc.subject organo-bridged silsesquioxane cs
dc.subject sol-gel process cs
dc.subject electrospinning cs
dc.subject Staphylococcus aureus cs
dc.subject Pseudomonas aeruginosa cs
dc.title (1S,2S)-Cyclohexane-1,2-diamine-based Organosilane Fibres as a Powerful Tool Against Pathogenic Bacteria cs
dc.identifier.doi 10.3390/polym12010206
local.relation.volume 12
local.relation.issue 1
local.identifier.publikace 7037
dc.identifier.orcid 0000-0002-7390-1243 Řezanka, Michal
dc.identifier.orcid 0000-0001-9719-6588 Máková, Veronika
dc.identifier.orcid 0000-0003-3395-6941 Rysová, Miroslava

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