A comparative study between chemically modified and copper nanoparticle immobilized Nylon 6 films to explore their efficiency in fighting against two types of pathogenic bacteria

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dc.contributor.author Swar, Sumita
dc.contributor.author Máková, Veronika
dc.contributor.author Horáková, Jana
dc.contributor.author Kejzlar, Pavel
dc.contributor.author Parma, Petr
dc.contributor.author Stibor, Ivan
dc.date.accessioned 2020-03-02T07:23:26Z
dc.date.available 2020-03-02T07:23:26Z
dc.date.issued 2020-01-05
dc.identifier.uri https://dspace.tul.cz/handle/15240/154592
dc.identifier.uri https://www.sciencedirect.com/science/article/pii/S0014305719318567
dc.description.abstract Hospital-acquired infections (HAI) caused by pathogenic bacteria such as Pseudomonas aeruginosa and Staphylococcus aureus adversely affect public health due to their colonization and subsequent formation of a biofilm on medical devices. Various functionalized polymers including polyamides are commonly used in the biomedical industry aiming to resist bacterial infection as well as to ensure cytocompatibility of the used materials. The present study is focused on the extension of our previous work that developed a new approach to immobilize mPEG on an amine-activated Nylon 6 surface. Herein, we compare functionalized samples of Nylon 6 together with samples additionally containing copper nanoparticles (Cu NPs, size 40-60 nm) physisorbed on a modified surface. Modified samples were analyzed via different techniques including water contact angle measurements, atomic force microscopy and scanning electron microscopy associated with energy dispersive Xray spectroscopy. The copper functionalized samples showed high antibacterial efficacy against Gram-positive Staphylococcus aureus and Gram-negative Pseudomonas aeruginosa. Moreover, most of the prepared samples were cytocompatible. cs
dc.format.extent 12 stran cs
dc.language.iso cs cs
dc.relation.ispartof EUROPEAN POLYMER JOURNAL
dc.subject Nylon 6 cs
dc.subject Punctionalization cs
dc.subject Copper nanoparticles cs
dc.subject Antibacterial activity cs
dc.subject Bacterial adhesion cs
dc.subject Cytocompatibility cs
dc.title A comparative study between chemically modified and copper nanoparticle immobilized Nylon 6 films to explore their efficiency in fighting against two types of pathogenic bacteria cs
dc.identifier.doi 0.1016/j.eurpolymj.2019.109392
local.relation.volume 122
local.identifier.publikace 6855
local.identifier.publikace 7665
dc.identifier.orcid 0000-0002-8150-861X Swar, Sumita
dc.identifier.orcid 0000-0001-9719-6588 Máková, Veronika
dc.identifier.orcid 0000-0003-2926-0570 Horáková, Jana
local.article.number UNSP 109392
dc.identifier.WebofScienceResearcherID A-8450-2018 Horáková, Jana


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